‘Build Out’ of Tower Floors Provides More Cancer Research Lab Space
2012 saw the “build out” of the previously unfinished fourth and fifth floors in Ohio State’s Biomedical Research Tower to provide an additional 64,000 square feet of lab space for OSUCCC – James investigators (32,000 gross square feet per floor). The fourth-floor “build out” was supported by an $8 million Extramural Research Facilities Improvement Program Construction Grant funded by the American Recovery and Reinvestment Act. The grant was awarded by the National Institutes of Health’s National Center for Research Resources based on an application submitted by Michael Grever, MD, and others. This floor houses labs for researchers in the Experimental Therapeutics Program. The fifth-floor project, supported in part by philanthropic revenue, houses labs that support the cancer program’s commitment to expanding solid tumor basic and genetic research.
NCI Grant Aids Study of microRNAs in CML
Danilo Perrotti, MD, PhD, of the Molecular Biology and Cancer Genetics Program at the OSUCCC – James, is principal investigator for a five-year, $1.52 million grant from the National Cancer Institute for studying the “Role of microRNAs in the Regulation of CML Stem Cell Survival and Self-Renewal.” Perrotti says chronic myelogenous leukemia (CML) is the first clinically cured stem cell-derived hematopoietic neoplasm, but he notes that tyrosine inhibitor therapy leaves behind a pool of CML stem cells that are resistant to these drugs. Thus, only drugs that can safely target these stem cells without harming normal ones have potential for disease eradication. He suggests that CML stem cell survival and renewal may depend on altered expression of certain microRNAs. With this grant, his team will examine the mechanism of altered microRNA expression for maintaining CML stem cells in hopes of finding therapeutic targets.
NCI Funds Ohio State Breast Cancer Intervention Training
Barbara Andersen, PhD, a professor of Psychology and researcher in the Cancer Control Program at the OSUCCC – James, received a $1.6 million grant from the National Cancer Institute (NCI) to train mental healthcare professionals in a biobehavioral intervention that helps cancer patients cope with stresses of diagnosis and treatment. Andersen and collaborators developed the intervention, which culminates more than a decade of research evaluating the benefits of psychological counseling and support for cancer survivors. She published studies in 2008, ’09 and ’10 showing benefits of this particular intervention, including a reduced risk for cancer recurrence. Andersen wants to disseminate the intervention “to increase the pool of mental healthcare providers who understand the needs of cancer patients and adopt evidence-based psychological treatments to help them.”