Need to Know 


The Genetically Engineered Mouse Modeling Shared Resource


Vincenzo Coppola, MD, director of the Genetically Engineered Mouse Modeling Shared Resource and a member of the Molecular Biology and Cancer Genetics Program

Mouse modeling is a powerful, highly effective tool for understanding cancer etiology and investigating novel experimental therapeutics. The OSUCCC – James Genetically Engineered Mouse Modeling Shared Resource is available to all Ohio State investigators who work or intend to work with mouse models of human diseases.

Director Vincenzo Coppola, MD, is a former scientist with the NCI's Mouse Cancer Genetics Program. He and his staff are particularly interested in helping investigators with minimal experience who would like to start using mouse models to complement and strengthen their in vivo studies or grant proposals.

The facility has extensive experience generating and maintaining genetically engineered mouse lines, including classical transgenic lines by pronuclear injection and targeted lines (knock-out, knock-in, conditional) by embryonic stem cell technology. The facility also offers sperm or embryo cryopreservation, rederivation and in vitro fertilization (IVF) services.

RT Now Available at JamesCare Comprehensive Breast Center


TOP: The new TrueBeam linear accelerator at the OSUCCC – James Comprehensive Breast Center.

Bottom: The Department of Radiation Oncology will be located on the second floor of the new Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, which is expected to open in 2014.

The JamesCare Comprehensive Breast Center, , which opened in April, now has its own TrueBeam linear accelerator and began offering radiation therapy for breast cancer patients in July. The OSUCCC – James Comprehensive Breast Center is the first of its kind in the Midwest to offer the full spectrum of breast cancer treatment – surgery, radiation therapy and chemotherapy – along with all-inclusive prevention, detection and survivorship services in one location.

Second Floor Please
When the new James Cancer Hospital and Solove Research Institute opens in 2014, patients arriving for radiation therapy will head to the Second Floor, rather than Ground Level, which is the typical location for a radiation oncology department.

"The new James Cancer Hospital will have one of the few radiation oncology departments that is located above ground," says Arnab Chakravarti, MD, chair of Radiation Oncology at the OSUCCC – James.

The 64,400 sq. ft. space will include:
• Seven treatment vaults, plus brachytherapy areas;
• 24 examination rooms and three consultation rooms;
• Separate registration areas for new patients and on-treatment patients;
• Waiting areas with natural light and interior rooms with more meditative designs;
• More spacious treatment vaults with storage to hide immobilization and treatment masks.

"We are putting a lot of thought into creating a calming, friendly environment to offer our patients the very best in personalized care in Radiation Oncology" Chakravarti says.


Multidisciplinary Management of Neuroendocrine Cancers:
From Standard of Care to Cutting-Edge Therapies

December 3, 2011
Focus: This symposium will review of the latest evidence-based information on the diagnosis and management of neuroendocrine cancers. The meeting will focus on the needs and practice gaps in
physician practice to improve patient outcomes by promoting multidisciplinary teams to address clinical and patient issues.
For more information, contact Nancy Jones at (614) 293-3688 or visit

Center for Retrovirus Research Award Announced
April 5, 2012
Ohio State's Center for Retrovirus Research in the College of Veterinary Medicine will award its 2012 Distinguished Research Career Award to Warner Greene, MD PhD, director of the Gladstone Institute of Virology and Immunology at University of California, San Francisco. Green focuses on the HIV-1 and HTLV-I retroviruses, which cause contrasting diseases: Acquired Immune Deficiency Syndrome (AIDS) with HIV-1, and the Adult T-cell Leukemia with HTLV-1.


For the 13th consecutive year, the OSUCCC – James earned a place on U.S.News and World Report's top 50 list of "America's Best Hospitals" for cancer care. This year, Ohio State's cancer program was ranked 20th in the nation by U.S.News, a significant jump from last year's impressive ranking of 26th. The OSUCCC – James first made the list in 1999, less than a decade after the hospital opened in July 1990, and has remained there ever since.

This ranking follows an "exceptional" rating of the OSUCCC – James by the National Cancer Institute earlier this year. "Exceptional" is the highest rating that the NCI gives to cancer centers around the country. More information on U.S.News rankings is available on its website,


Almost 5,000 riders and some 1,700 volunteers joined forces to ensure the success of Pelotonia '11, the annual bicycling tour to raise money for cancer research at the OSUCCC – James. As of early September, the Aug. 20 weekend-long ride between Columbus and Athens, Ohio, had raised nearly $9.4 million.

The event attracted riders from 38 states and four nations. More than 1,000 riders constituted Team Buckeye, the official Ohio State University super peloton (riding group).

Fundraising for Pelotonia '11 will continue through Oct. 21, but revenue from this year's ride is expected to push the overall three-year total to more than $21 million. Last year's tour generated $7.8 million, and the 2009 inaugural Pelotonia raised $4.5 million.

Some of the money raised supports the Pelotonia Fellowship Program, which has provided 120 students with money to pursue innovative ideas in cancer research. To learn about some of the 2011 Pelotonia Fellowship recipients, see page 28.

For more information about Pelotonia, visit

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