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NUCLEIC ACID SHARED RESOURCE ADDS NEW TECHNOLOGIES AND APPLICATIONS

The OSUCCC - James Nucleic Acid Shared Resource (NASR) provides genomic support for biomedical research, including Sanger sequencing, next-generation sequencing, genotyping, methylation and gene-expression analysis. Recently, the facility extended its next-generation sequencing by adding an Ion PGM Sequencer (Life Technologies) and its gene expression analytical capabilities with a QuantStudio™ 12K Flex system. New applications were added to the nCounter System (NanoString Technologies).

ION PGM SEQUENCER

The NASR introduced the Ion PGM Sequencer in early 2012. Life Technologies' Ion Torrent is based on electrical detection (i.e., pH change) of base extension.

The Ion PGM sequencer is ideal for sequencing genes, small genomes and panels of genes, or for performing gene expression profiling. Total workflow, from DNA to sequence, takes about eight hours for 200 base-reads on an Ion 314 Chip. Three Ion semiconductor chips are available: The Ion 314, the Ion 316 and the Ion 318 (stated output, 10 megabases, 100 megabases and 1 gigabase of sequence data, respectively).

GENE EXPRESSION ANALYSIS

The QuantStudio™ 12K Flex system
A new QuantStudio™ 12K Flex system adds extra capacity to the NASR's three Applied Biosystems 7900HT Fast Real-Time PCR Systems and its two Applied Biosystems StepOnePlus Real-Time PCR Systems. Extra capacity will be reflected in the OpenArray format for effortless scaling from 1 to 12,000 data points in a single run and the simple OpenArray workflow, including the Accufill System.

NEW COUNTER APPLICATIONS

NanoString's nCounter technology detects target molecules using color-coded molecular barcodes, providing a digital count of target molecules. The NASR has added two new applications to its nCounter system:
  • miRGE analysis: Permits profiling of 100-200 mRNA targets and 5-30 miRNA targets in a single reaction.
  • nCounter single-cell expression assay: Provides ultra-sensitive, reproducible and highly multiplexed gene-expression profiling from single cells or with as little as 10pg of total RNA. The assay linearly amplifies up to 800 target transcripts from a single cell in a single tube without bias.
Please visit the NASR for more information or send an email to Hansjuerg.Alder@osumc.edu.


EVENTS CALENDAR

UPDATE IN ROBOTIC SURGERY ACROSS DISCIPLINES
March 22, 2013, THE OHIO STATE UNIVERSITY BIOMEDICAL RESEARCH TOWER

This all-day CME-certified workshop will enable participants to:
  • Identify applications for robotic surgery across surgical specialties
  • Review emerging issues related to new robotics techniques
  • Define patient populations that can benefit from robotic surgery
  • Describe the potential benefits of robotic surgery over open surgery
Pre-registration is required for this free workshop.
Visit ccme.osu.edu/ConferenceDetail.aspx?ID=1231


PELOTONIA13
August 9-11

Pelotonia is an annual bicycling event that takes riders through bucolic Ohio countryside on routes of varying length. The event attracts thousands of cyclists from across the nation, and 100 percent of the funds raised supports cancer research at the OSUCCC - James.

For information or to register as a rider or volunteer, visit www.pelotonia.org.


SECOND FLOOR: RADIATION ONCOLOGY

The OSUCCC - James Department of Radiation Oncology will occupy the second floor of the new James Cancer Hospital and Solove Research Institute when construction is complete.

On page 24 of this issue of Frontiers, Arnab Chakravarti, MD, chair of Radiation Oncology, and a group of OSUCCC - James investigators were photographed in the unfinished second-floor space, in one of seven "vaults" that will house linear accelerators (linacs).

A second-floor perch is unusual for a radiation therapy department - most such facilities are located below ground - but when it opens in 2014, its windows will allow natural daylight to enter from the north and south, providing a more cheerful treatment environment. Twenty-four patient exam rooms are designed to make visits as comfortable and convenient as possible for patients.

Adding the Radiation Oncology department to the new hospital was made possible by a $100 million competitive grant awarded to Ohio State by the federal Health Resources Services Administration.

The Radiation Oncology area is also equipped with computerized tomography (CT), positron emission tomography/CT and magnetic resonance imaging. Each imaging modality has particular advantages and is used to simulate and customize radiation treatment for each patient. Integrating these imaging modalities with treatment delivery by the most technologically advanced linear accelerators will result in the best care possible for patients treated at the OSUCCC - James.

FACTS ABOUT THE SECOND FLOOR AND THE LINAC VAULTS
At 27 million pounds, the second floor is the heaviest component of the building. It required redesigning the building's foundation and structure and adding 263 concrete piles to support the weight, and additional and heavier-gauge columns had to be incorporated into the structural support.
  • The department's seven linacs each weigh 65,000 pounds;
  • The vaults that contain the linacs are built of specialized concrete, steel and lead to contain the radiation.
  • The vaults' floors and ceilings are about five feet thick and constructed of concrete that includes 8.2 million pounds of a special high-density aggregate made of hematite mined in South Africa and supplemented by lead shot.
  • The walls are about two feet thick and made of a proprietary high-density brick (visible in the photograph on page 24). About 139,000 of the bricks, totaling 5.1 million pounds, were used to shield the walls of the seven linacs, a brachytherapy suite (a specialized operating room for delivering localized high-dose radiation), and an operating room on the fourth floor that offers intraoperative radiation therapy.




PELOTONIA TOTAL TOPS $42 MILLION IN JUST FOUR YEARS

Riders and donors in Pelotonia 12, the annual grassroots bicycle tour that generates money for cancer research at the OSUCCC - James, raised a record $16,871,403, a 28-percent increase over the Pelotonia 11 total of $13.1 million.

This year’s tally brings the four-year fundraising total for Pelotonia, which began in 2009, to more than $42 million. Pelotonia 12, which took place Aug. 10-12 on routes between Columbus and Kenyon College in Gambier, Ohio, drew a record 6,212 riders from 43 states and three countries, as well as 3,141 virtual riders and more than 2,000 volunteers. Measured by riders, Pelotonia this year became the largest single-event biking fundraiser in the nation.

Participants included a record 1,635 members of Team Buckeye, the official superpeloton (riding group) for The Ohio State University. The team included 1,198riders, 336 virtual riders and 101 volunteers. Team Buckeye comprised 84 pelotons and collectively raised more than $2.1 million.

"Everyone associated with Pelotonia should be proud of what we are accomplishing," says OSUCCC Director and James CEO Michael A. Caligiuri, MD. "At a time when government funding for cancer research is hard to obtain, we have stepped forward to raise money ourselves. And not just a little money: more than $42 million in four years is the kind of financial firepower that enables us to confidently proclaim that we will one day conquer this disease in its many forms."

Thanks to generous sponsors – Huntington Bank, Limited Brands Foundation, Richard and Peggy Santulli, American Electric Power Foundation, Nationwide Insurance, Cardinal Health Foundation, JP Morgan Chase and The Scotts Miracle-Gro Company - 100 percent of every dollar raised by Pelotonia goes to support cancer research at the OSUCCC - James.

Pelotonia 13 is scheduled for Aug. 9-11. Register at www.pelotonia.org.


THE JAMES EARNS 'TOP HOSPITAL' STATUS FOR FIFTH TIME IN SIX YEARS

For the fourth consecutive year, and the fifth time in six years, the OSUCCC - James has been named one of the safest and most effective hospitals in the country by The Leapfrog Group, a national consortium of Fortune 500 companies that pay for healthcare needs for an estimated 37 million Americans.

Only one other cancer hospital has earned this honor four years in a row. The James is among 92 hospitals from a field of almost 1,200 to be named 2012 Leapfrog Top Hospitals based upon a rating system that provides an up-to the- minute assessment of a hospital's quality and safety. A complete list of 2012 Leapfrog Top Hospitals can be viewed at www.leapfroggroup.org.

 
13-Feb-13
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