A Gene Within a Gene Contributes to the Aggressiveness of Acute Myeloid Leukemia
High expression of a gene called BAALC is known to be associated with poor survival of acute myeloid leukemia (AML) patients.
BAALC has a second smaller gene embedded within it that is also active in
Study Identifies a Likely Key Driver of Colorectal Cancer Development and Progression
New targets are needed for agents that will more effectively treat colorectal cancer (CRC).
This study identifies a molecule that is probably a key driver of colorectal cancer.
The findings strongly
Ohio State Hematologist Recognized Nationally With Top 10 Clinical Research Achievement Award
COLUMBUS, Ohio – John C. Byrd, MD, has again received national scientific recognition for his translational research investigating use of the drug, ibrutinib, in the treatment of chronic lymphocytic l
Well-Known Cancer Gene NRAS Produces Five Variants, Study Finds
NRAS is one of the most studied cancer-related genes.
This study found that the gene produces five variants, not just one form as thought.
The finding might help improve drugs for cancers that i
Ohio State Recognizes Cancer ‘Champions’ at April 9 Awards Luncheon
Honorees selected from Ohio, Wisconsin and California
COLUMBUS, Ohio – Four individuals, a grassroots fundraising organization and major corporation will be recognized as cancer “champions” W
Innovative ‘False Pedicle’ Surgery Allows for Advanced Spinal/Pelvic Reconstruction
Ohio State team pioneers surgical technique to stabilize the spine and pelvis in complex bone cancer removal
COLUMBUS, Ohio – A multidisciplinary team at The Ohio State University Comprehensive C
Inhibition of CDK4 Might Promote Lymphoma Development and Progression
Inhibitors of CDK4, a protein that helps regulate the cell cycle, have been shown to inhibit cancer in some tumor types.
This new study found that inhibiting this molecule can cause genetic instabilit
Ohio State Partners with MedVax Technologies, Inc. to Bring a Cancer Peptide Vaccine to Patients
COLUMBUS, Ohio, and MIAMI, Florida – The Ohio State University, through the Ohio State Innovation Foundation, has signed an exclusive world-wide licensing agreement with MedVax Technologies, Inc., for
Study Identifies Possible New Target for Future Brain Cancer Drugs
Glioblastoma multiforme (GBM) is a lethal brain cancer that has an average survival of 15 months, so there is a critical need for new treatments.
This study found that GBM tumors that have high lev
Study of ‘Super Responder’ Reveals Possible New Gene Target for Lung Cancer
COLUMBUS, Ohio — A potential new gene mutation that might drive lung cancer development and growth has been identified by researchers at The Ohio State University Comprehensive Cancer Center – Arthur
Addition of Bevacizumab to the Treatment of Newly Diagnosed Glioblastoma Brain Tumors Does Not Extend Patients’ Lives
COLUMBUS, Ohio – Results from a randomized, phase 3 clinical trial conducted by the Radiation Therapy Oncology Group (RTOG) have shown that adding bevacizumab, a drug that inhibits the growth of blood
Ohio State Cancer Research Played a Significant Role in FDA Approval of Important New CLL Drug
COLUMBUS, Ohio – On Feb. 12, 2014, the U.S. Food and Drug Administration expanded the approved use of the drug ibrutinib to chronic lymphocytic leukemia (CLL).
Much of the clinical and basic-scienc
Study Reveals How Cancer Cells Thrive in Oxygen-Starved Tumors
Growing tumors often have areas of low oxygen, a condition called hypoxia.
How cancer cells survive and thrive under the stress of hypoxia is poorly understood.
This study shows how cancer cells cha
Yoga Can Lower Fatigue, Inflammation in Breast Cancer Survivors
In study, the more
women practiced, the better their results
COLUMBUS, Ohio -- Practicing yoga for as little as three months can reduce fatigue and lower in
Number of Cancer Stem Cells Might Not Predict Outcome in HPV-Related Oral Cancers
COLUMBUS, Ohio – New research from The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) suggests that it ma
Ohio State Awarded $11.3 Million for Thyroid Cancer Research
Prestigious National Cancer Institute SPORE grant third for cancer center
COLUMBUS, Ohio –The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital
AML Score That Combines Genetic and Epigenetic Changes Might Help Guide Therapy
Guido Marcucci, MD
Currently, treatments for adult acute myeloid leukemia (AML) are determined mainly using the chromosome changes and gene mutations present in AML cells.
In this study, researchers
Laboratory Study Confirms Target of Potent Chronic Leukemia Drug
Jennifer Woyach, MD
The experimental drug ibrutinib can be exceptionally effective in treating chronic leukemia, but it is unclear whether its primary target, a molecule called BTK, is important for
Tomato-Rich Diet Increases Hormone Linked to Reduced Breast Cancer Risk in Postmenopausal Women
COLUMBUS, Ohio – A tomato-rich diet could help protect at-risk postmenopausal women from breast cancer, according to new research from The Ohio State University Comprehensive Cancer Center – Arthur G.
Pelotonia Riders Pedal to a Record $19 Million for Cancer Research
Fundraising total of $61 million for first five years
COLUMBUS, Ohio - Pelotonia has announced record fundraising of more than $19 million for its 2013 ride.
From August 10-11, 2013, 6,723
Nine More Big Ideas in Cancer Research at Ohio State Funded by Pelotonia
COLUMBUS, OHIO—New treatments that target markers in individual cancers; packaging a novel leukemia drug in nano-sized bubbles of fat; and a national cancer disparities research network are among the
Next-Generation Genome Screening Is Step Toward Precision Cancer Medicine for Lung Cancer
DNA analysis helps doctors identify drugs to more precisely target individual patient tumors
COLUMBUS, Ohio – Precision cancer medicine has taken a strong step forward at the Ohio State Universi
HPV Can Damage Genes and Chromosomes Directly, Sequencing Study Shows
Maura Gillison, MD, PhD
Human papillomavirus (HPV) causes cervical, head and neck, anal and other cancers.
How it causes cancer isn’t completely known.
This study shows that HPV can damage genes a
Ohio State Trial Tests Novel Two-Drug Combination for Triple Negative Breast Cancers
COLUMBUS, Ohio -- Breast cancer researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital & Richard J. Solove Research Institute (OSUCCC – James) are test
Genomic Medicine Pioneer to Present Annual Block Lecture at Ohio State
COLUMBUS, Ohio – Eric S. Lander, PhD, president and founding director of the Broad Institute of the Massachusetts Institute of Technology and Harvard University, will receive the 20th annual Herbert a
Cancer Wasting Due in Part to Tumor Factors That Block Muscle Repair, Study Shows
Cancer wasting causes 20-25 percent of cancer deaths.
Tumor growth causes the condition, which has no treatment.
This study shows that cancer wasting is due in part to tumor factors that block muscl
Ohio State Testing a New Spice Derivative Formulation for Breast Cancer Prevention
COLUMBUS, Ohio – A clinical trial at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) investigates wh
Minimally Invasive Surgery Helps Young Cancer Patients Maintain Fertility
COLUMBUS, Ohio – Although the human papillomavirus (HPV) vaccine, pap smears and increased public awareness have reduced cervical cancer rates in the United States, the disease still affects at least
Ohio State’s James Cancer Hospital Receives Highest Nursing Recognition With Prestigious Magnet® Designation
COLUMBUS, Ohio - The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) has achieved Magnet® designation as
The Ohio State University Partners with Microlin Bio Inc. to Bring the University’s Transformational Cancer Discoveries to Patients
Largest Ohio State licensing agreement in more than a decade
COLUMBUS, Ohio, and NEW YORK–The Ohio State University today announced the signing of an exclusive world-wide agreement with Microlin
MicroRNA-31 Might Predict Lung-Cancer Spread
Determining whether lung cancer has spread is critical for identifying the most effective therapy.
This study found that high levels of microRNA-31 indicate that the tumor has spread and signals a p
Ohio State Receives $18.7 Million Federal Grant to Establish Tobacco Center of Regulatory Science
Multidisciplinary Research Will Inform FDA in New
COLUMBUS, Ohio – The Ohio State University has received an $18.7 million federal grant to establish a research center devoted to t
MicroRNA Molecule Found to be a Potent Tumor-Suppressor in Lung Cancer
Carlo M. Croce, MD
A microRNA called miR-486 is known to play a role in several solid tumors but its mechanism of action in lung cancer is not known.
This study shows that miR-486 is a potent tumor
NCI Renews Support for Major Thyroid-Cancer Research Effort at Ohio State
COLUMBUS, Ohio – The National Cancer Institute (NCI) has awarded a five-year, $11.3 million grant to a team of researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James
Proteins in Histone Group Might Influence Cancer Development, Study Shows
Histone proteins play a crucial role in DNA packaging.
It has been thought that proteins called “replication-dependent histone isoforms” all behaved the same way.
This study shows that proteins in t
Study Shows How Stress Gene Enables Cancer To Spread
Ohio – In an unexpected finding, scientists have linked the activation of a stress
gene in immune-system cells to the spread of breast cancer to other parts of
Loss of MicroRNA Decoy Might Contribute to Development of Soft-Tissue Sarcoma
Soft-tissue sarcomas are rare cancers that affect mainly children and that respond poorly to treatment.
This study discovered molecular events that may help these malignancies develop.
Researchers Target HER1 Receptor for Peptide Cancer Vaccine, Therapeutic Agents
Small proteins called peptides offer potentially safer, more effective and less costly alternatives to antibody-based drugs now used to treat many cancers.
This study identifies two regions on an im
Nano Drug Crosses Blood-Brain Tumor Barrier, Targets Brain Tumor Cells and Blood Vessels
The blood-brain barrier protects the brain from poisons but also prevents drugs from reaching brain tumors; innovative new treatments are needed.
This laboratory study shows that a nanotechnology dru
Ohio State Athletics Peloton Hosts Movie Nights to Support Pelotonia, Cancer Research
COLUMBUS, Ohio – The Ohio State University Athletics Peloton, which is part of Team Buckeye, will hold three movie nights in different Ohio State athletic facilities to raise funds for this year’s Pel
Ohio State's Wexner Medical Center Performing Fecal Transplants To Treat Serious Intestinal Infections
Ohio – After suffering for more than a year with severe diarrhea and fatiguedue
to an intestinal infection caused by the “superbug” Clostridium difficile, or C.
diff as it is more co
Ohio State Cancer Expert Separates Facts Of Sun Safety From Fiction
COLUMBUS, Ohio – From new “sunscreen” pills to a wide range of SPF numbers, consumers may
be confused this summer when trying to protect themselves from the sun’s
JEGS Automotive to Showcase Race Cars at the New James
COLUMBUS, Ohio – Race car drivers with JEGS Automotive Inc. will pass out 1,500 homemade cookies and meet with construction workers helping to build the new James Cancer Hospital and Solove Research
Drug Shows Potential as Safe and Effective for Chronic Leukemia, Mantle Cell Lymphoma
Kristie Blum, MD
Clinical results published online in NEJM show ibrutinib significantly prolongs survival in all classes of chronic lymphocytic leukemia (CLL) patients, even those at high-risk of rec
Study Shows How the Nanog Protein Promotes Growth of Head and Neck Cancer
A protein called Nanog helps the renewal of healthy embryonic stem cells.
This study shows that Nanog also promotes cancer stem cell proliferation in head and neck cancer and shows how it promotes th
Metabolic Molecule Drives Growth Of Aggressive Brain Cancer
Genomic research has shown that glioblastoma, the most dangerous type of brain cancer, has four subtypes.
This study examines two of the subtypes and identifies an abnormal metabolic pathway that dri
Shapiro Appointed Chair-Elect for ASCO Survivorship Committee
COLUMBUS, Ohio – Dr. Charles Shapiro, director of breast medical oncology at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Reseach Inst
JEGS Foundation Donates $10 Million To New Cancer Hospital At Ohio State
COLUMBUS, Ohio – The Coughlin family who own JEGS Automotive Inc., one of the largest and most successful automotive equipment companies in the nation and a record-breaking racing team, recently made
Ohio State Cancer Expert Appointed to National Dietary Guidelines Advisory Committee
COLUMBUS, Ohio –Steven Clinton,MD, PhD, program leader of molecular carcinogenesis and chemoprevention at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and R