Multi-Center Lung Cancer Risk Test Includes Ohio State  

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Posted: 11/17/2009

COLUMBUS, Ohio – Ohio State University Medical Center is one of six medical centers in the United States awarded a two-year, $1.6 million grant from the National Cancer Institute to validate the accuracy of a multi-gene lung cancer risk test in longtime smokers.

The test measures 14 key antioxidant, DNA repair and regulatory genes in normal bronchial cells as a predictor for the presence of, or risk for, lung cancer. The cells are sampled during a bronchoscopy, a procedure that allows a doctor to examine a patient’s throat, larynx, trachea and lower airways using a thin viewing instrument called a bronchoscope.

Previous smaller studies have shown that these 14 genes accurately predict the presence of lung cancer in a cohort of high-risk smokers.

“This is an exciting opportunity,” says Dr. Patrick Nana-Sinkam, lead investigator at Ohio State’s Medical Center. “If validated, this test could identify those high-risk individuals who may benefit from chemoprevention and screening studies.”

In December, Ohio State will start recruiting 125 participants age 50 and older who have at least a 20-pack year history of smoking, says Nana-Sinkam, a pulmonologist and critical care specialist at the Center for Critical Care at Ohio State’s Medical Center. Pack years are calculated by the taking the number of years smoking multiplied by packs smoked per day, said Nana-Sinkam.

These patients will be among more than 1,000 enrolled nationally in the study.

The grant was awarded through the National Institutes of Health’s new Research and Research Infrastructure “Grand Opportunities” (GO) grants program, established through the American Recovery and Reinvestment Act. GO grants support projects that address large biomedical and bio-behavioral research endeavors that promote the growth of, and investment in, biomedical research and development, public health, and healthcare delivery.

Lung cancer – typically detected at an advanced stage – is the leading cause of cancer mortality in both men and women in the United States, with cigarette smoking being the primary known risk factor, said Nana-Sinkam, who also is a researcher at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

Other institutions involved in the multi-center study include the University of Toledo, Henry Ford Hospital, Case Western, Mayo Clinic and Vanderbilt University.

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Eileen Scahill
Medical Center Communications

Tags: Cancer; Clinical/Translational Research; James Cancer Hospital; Lung Cancer; Lung Diseases; OSU Medical Center

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: