About Childhood Medulloblastoma

Childhood Medulloblastoma Treatment (PDQ®)

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General Information About Childhood Medulloblastoma

Key Points:

Childhood medulloblastoma is a disease in which benign (noncancer) or malignant (cancer) cells form in the tissues of the brain.

Childhood medulloblastoma (tumor) usually forms in the cerebellum, which is at the lower back of the brain. The cerebellum is the part of the brain that controls movement, balance, and posture. Childhood medulloblastoma may also be called primitive neuroectodermal tumor (PNET).

About 1 out of 5 childhood brain tumors are medulloblastomas. Although cancer is rare in children, brain tumors are the most common type of childhood cancer other than leukemia and lymphoma.

This summary refers to the treatment of primary brain tumors (tumors that begin in the brain). Treatment for metastatic brain tumors, which are tumors formed by cancer cells that begin in other parts of the body and spread to the brain, is not discussed in this summary. See the PDQ treatment summary on Childhood Brain Tumors for information about the different types of childhood brain and spinal cord tumors.

Brain tumors can occur in both children and adults; however, treatment for children may be different than treatment for adults. (See the PDQ treatment summary on Adult Brain Tumors for more information.)

The cause of most childhood brain tumors is unknown.

The signs of childhood medulloblastoma vary and often depend on the child’s age and where the tumor is located.

Symptoms caused by medulloblastoma may also be caused by other conditions. A doctor should be consulted if any of the following problems occur:

  • Loss of balance, trouble walking, worsening handwriting, or slow speech.
  • Morning headache or headache that goes away after vomiting.
  • Nausea and vomiting.
  • Unusual sleepiness or change in energy level.
  • Change in personality or behavior.
  • Unexplained weight loss or weight gain.

Tests that examine the brain and spinal cord are used to detect (find) childhood medulloblastoma.

The following tests and procedures may be used:

  • CT scan (CAT scan): A procedure that makes a series of detailed pictures of areas inside the body, taken from different angles. The pictures are made by a computer linked to an x-ray machine. A dye may be injected into a vein or swallowed to help the organs or tissues show up more clearly. This procedure is also called computed tomography, computerized tomography, or computerized axial tomography.
  • MRI (magnetic resonance imaging) with gadolinium: A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the brain and spinal cord. A substance called gadolinium is injected into a vein. The gadolinium collects around the cancer cells so they show up brighter in the picture. This procedure is also called nuclear magnetic resonance imaging (NMRI).

Childhood medulloblastoma is diagnosed and removed in surgery.

If a brain tumor is suspected, a biopsy is done by removing part of the skull and using a needle to remove a sample of the tumor tissue. A pathologist views the tissue under a microscope to look for cancer cells. If cancer cells are found, the doctor will remove as much tumor as possible during the same surgery.

Certain factors affect prognosis (chance of recovery) and treatment options.

The prognosis (chance of recovery) and treatment options depend on:

  • The age of the child when the tumor is found.
  • The location of the tumor.
  • The amount of tumor remaining after surgery.
  • Whether the cancer has spread to other parts of the central nervous system (brain and spinal cord), or to other parts of the body, such as the bones.
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Stages of Childhood Medulloblastoma

Key Points:

After childhood medulloblastoma has been diagnosed, tests are done to find out if there is tumor remaining or if cancer cells have spread.

The extent or spread of cancer is usually described as stages. For childhood medulloblastoma, risk groups are used instead of stages. Risk groups are described by the amount of remaining tumor or spread of cancer cells within the central nervous system (brain and spinal cord) or to other parts of the body. It is important to know the risk group in order to plan treatment. The following tests and procedures may be used to determine the risk group:

  • MRI (magnetic resonance imaging) with gadolinium: A procedure that uses a magnet, radio waves, and a computer to make a series of detailed pictures of areas inside the brain and spinal cord. A substance called gadolinium is injected into a vein. The gadolinium collects around the cancer cells so they show up brighter in the picture. This procedure is also called nuclear magnetic resonance imaging (NMRI).
  • Lumbar puncture: A procedure used to collect cerebrospinal fluid from the spinal column. This is done by placing a needle into the spinal column. This procedure is also called an LP or spinal tap.
  • Bone marrow aspiration and biopsy: The removal of bone marrow, blood, and a small piece of bone by inserting a hollow needle into the hipbone or breastbone. A pathologist views the bone marrow, blood, and bone under a microscope to look for signs of cancer.
  • Bone scan: A procedure to check if there are rapidly dividing cells, such as cancer cells, in the bone. A very small amount of radioactive material is injected into a vein and travels through the bloodstream. The radioactive material collects in the bones and is detected by a scanner.

The following risk categories are used for childhood medulloblastoma:

Average risk

Childhood medulloblastoma is called an average risk if all of the following are true:

  • The child is older than 3 years of age.
  • The tumor is at the very back of the brain.
  • All of the tumor was removed by surgery or there was a very small amount remaining.
  • The cancer has not spread to other parts of the body.

Poor risk

Childhood medulloblastoma is called a poor risk if any of the following are true:

  • The child is younger than 3 years of age.
  • The tumor is not at the very back of the brain.
  • Some of the tumor was not removed by surgery.
  • The cancer has spread to other parts of the body.

In general, cancer is more likely to recur (come back) in patients in the poor risk group.

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Recurrent Childhood Medulloblastoma

    Recurrent childhood medulloblastoma is a tumor that has recurred (come back) after it has been treated. Childhood medulloblastoma often recurs. A tumor may come back many years later at the same place or a different place in the brain. It can also come back in other parts of the body such as the spinal cord.

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    Treatment Option Overview

    Key Points:

    There are different types of treatment for children with childhood medulloblastoma.

    Different types of treatment are available for children with childhood medulloblastoma. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.

    Because cancer in children is rare, taking part in a clinical trial should be considered. Clinical trials are taking place in many parts of the country. Information about ongoing clinical trials is available from the NCI Web site. Choosing the most appropriate cancer treatment is a decision that ideally involves the patient, family, and health care team.

    Children with medulloblastoma should have their treatment planned by a team of doctors with expertise in treating childhood brain tumors.

    Treatment will be overseen by a pediatriconcologist, a doctor who specializes in treating children with cancer. The pediatric oncologist works with other pediatric doctors who are experts in treating children with brain tumors and who specialize in certain areas of medicine. These may include the following specialists:

    Some cancer treatments cause side effects months or years after treatment has ended.

    Some cancer treatments cause side effects that continue or appear months or years after cancer treatment has ended. These are called late effects. Late effects of cancer treatment may include:

    • Physical problems.
    • Changes in mood, feelings, thinking, learning or memory.
    • Second cancers (new types of cancer).

    Some late effects may be treated or controlled. It is important to talk with your child's doctors about the possible late effects caused by some treatments. (See the PDQ summary on Late Effects of Treatment for Childhood Cancer for more information).

    Four types of standard treatment are used:

    Surgery

    Surgery is used to diagnose and treat childhood medulloblastoma as described in the General Information section of this summary.

    Radiation therapy

    Radiation therapy is a cancer treatment that uses high-energy x-rays or other types of radiation to kill cancer cells or keep them from growing. There are two types of radiation therapy. External radiation therapy uses a machine outside the body to send radiation toward the cancer. Internal radiation therapy uses a radioactive substance sealed in needles, seeds, wires, or catheters that are placed directly into or near the cancer. The way the radiation therapy is given depends on the type and stage of the cancer being treated.

    Radiation therapy to the brain can affect growth and development in young children. For this reason, ways of giving radiation therapy that limit damage to healthy brain tissue are being studied.

    Chemotherapy

    Chemotherapy is a cancer treatment that uses drugs to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. When chemotherapy is taken by mouth or injected into a vein or muscle, the drugs enter the bloodstream and can reach cancer cells throughout the body (systemic chemotherapy). When chemotherapy is placed directly into the spinal column, an organ, or a body cavity such as the abdomen, the drugs mainly affect cancer cells in those areas (regional chemotherapy). The way the chemotherapy is given depends on the type and stage of the cancer being treated.

    Because radiation therapy can affect growth and brain development in young children, clinical trials are studying ways of using chemotherapy to delay or reduce the need for radiation therapy.

    Cerebrospinal fluid diversion

    Cerebrospinal fluid diversion is a method used to drain fluid that has built up around the brain and spinal cord. A shunt (long, thin tube) is placed in a ventricle (hollow space) of the brain and threaded under the skin to another part of the body, usually the abdomen. The shunt carries excess fluid away from the brain so it may be absorbed elsewhere in the body.

    New types of treatment are being tested in clinical trials. These include the following:

    High-dose chemotherapy with stem cell transplant

    High-dose chemotherapy with bone marrow or stem cell transplant is a way of giving high doses of chemotherapy and replacing blood-forming cells destroyed by the cancer treatment. Stem cells (immature blood cells) are removed from the blood or bone marrow of the patient or a donor and are frozen and stored. After the chemotherapy is completed, the stored stem cells are thawed and given back to the patient through an infusion. These reinfused stem cells grow into (and restore) the body’s blood cells.

    This summary section refers to specific treatments under study in clinical trials, but it may not mention every new treatment being studied. Information about ongoing clinical trials is available from the NCI Web site.

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    Treatment Options for Childhood Medulloblastoma

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      Untreated Childhood Medulloblastoma

        Untreated childhood medulloblastoma is a tumor for which no treatment has been given. The child may have received drugs or treatment to relieve symptoms caused by the tumor.

        Standard treatment of average risk childhood medulloblastoma is usually surgery and radiation therapy to the brain and spinal cord, with or without chemotherapy.

        One of the treatments being studied in clinical trials for average risk medulloblastoma in children 3 years and older is surgery followed by radiation therapy (including conformal radiation therapy), with chemotherapy during and after radiation therapy.

        Standard treatment of poor risk childhood medulloblastoma may include surgery followed by radiation therapy to the brain and spinal cord, with or without chemotherapy.

        One of the treatments being studied in clinical trials for poor risk childhood medulloblastoma is surgery followed by radiation therapy to the brain and spinal cord, followed by high-dose chemotherapy with stem cell transplant.

        Treatment of childhood medulloblastoma in children younger than 3 years of age is usually within a clinical trial and may include the following:

        • Surgery followed by chemotherapy to delay radiation therapy.
        • Surgery followed by high-dose chemotherapy with stem cell transplant.
        • Chemotherapy only.
        • Chemotherapy followed by conformal radiation therapy.

        Information about these and other ongoing clinical trials is available from the NCI Web site.

        Check for clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with untreated childhood medulloblastoma.

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        Recurrent Childhood Medulloblastoma

          Standard treatment of recurrent childhood medulloblastoma may include surgery with or without chemotherapy and/or stereotactic radiation therapy.

          Some of the treatments being studied in clinical trials for recurrent childhood medulloblastoma include the following:

          Information about these and other ongoing clinical trials is available from the NCI Web site.

          Check for clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with recurrent childhood medulloblastoma.

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          Changes to This Summary (06/21/2007)

            The PDQcancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

            Changes were made to this summary to match those made to the health professional version.

            The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu