Diagnosis & Treatment of Multiple Myeloma

As cancer specialists, the healthcare professionals at Ohio State’s Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute are dedicated to providing the best care and support for you and your family. Our team is made up of an interdisciplinary group that includes cancer doctors with a specialty in Multiple Myeloma as well as pathologists, radiologists, oncology nurses and patient coordinators.


The prognosis (chance of recovery) depends on the following:
• The type of plasma cell neoplasm
• The stage of the disease
• Whether a certain immunoglobulin (antibody) is present
• Whether the kidney is damaged
• Whether the cancer responds to initial treatment or recurs (comes back)


Treatment options depend on the following:
• The type of plasma cell neoplasm
• The age and general health of the patient
• Whether there are health problems related to the disease
• Whether the cancer responds to initial treatment or recurs (comes back)

Treatment Options:
Patients without symptoms may not need treatment.  When symptoms appear, treatment of multiple myeloma may include the following:
• High-dose corticosteroid therapy
• Thalidomide or Lenalidomide therapy
• Combination chemotherapy
• High-dose chemotherapy and hematopoietic stem cell transplant (a.k.a. bone marrow transplant)
• Biologic therapy with monoclonal antibodies
• Radiation therapy for symptomatic tumors in different bones, often in the spine
• A clinical trial of combination therapy
• Bisphosphonate drug therapy may be given to slow bone loss and reduce bone pain

Risk Factors

For multiple myeloma and plasmacytoma, risk factors include:
• Being male
• Being African American
• Having a brother or sister who has multiple myeloma
• Being exposed to atomic bomb radiation

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu