Allogeneic

Physician Consultation Outpatient Visit

  • Meet with transplant physician
  • Review past medical history & treatment
  • Discuss treatment options
  • Discuss phases of transplantation
  • Recommend additional treatment if indicated
  • Initiate insurance verification, transplant benefits and approval
  • Initiate donor search through siblings or National Marrow Donor Program (NMDP), if appropriate


Pre-transplant Evaluation for Recipient & Donor

Recipient:

  • History & Physical examination
  • Chest X-ray
  • Electrocardiogram
  • MUGA
  • Pulmonary Function Tests (PFTs)
  • Bloodwork, including viral titers
  • Disease staging studies as needed (ie: CT scans, myeloma survey)
  • Other tests as needed (ie: bone marrow aspirate & biopsy, lumbar puncture)
  • Educational session to learn more about transplant
  • Obtain insurance approval after pre-transplant evaluation completed

Donor:

  • History and Physical
  • Electrocardiogram
  • Chest X-ray
  • Bloodwork

Apheresis or Collection of Peripheral Blood Stem Cells (PBSCs) (if applicable)

  • Donors will be given a medication (ie: Neupogen) by subcutaneous injection at home to move stems cells from the bone marrow into the blood
  • Apheresis will begin approximately 5 days after Neupogen started
  • Apheresis or donor stem cell collection is initiated on the same day of the infusion (Day 0)
  • Apheresis is done everyday until sufficient PBSCs are collected
  • Apheresis takes about 4-6 hours each day for about 1-2 days
  • Donor will continue to take Neupogen injections until apheresis is completed

Transplant Hospital Admission

  • Scheduled within about 30 days after completion of the pre-transplant evaluation
  • Average of a 4 to 6 week hospital stay
  • Central Venous Catheter (CVC) placement done on the day of admission (if appropriate)
  • Preparative regimen will be given (chemotherapy with or without total body irradiation)
  • Patient education handouts provided about what to expect
  • Stem cells will be collected from the donor on day 0

Follow-up Care

  • Outpatient clinic visits 2-3 times a week for about 2 - 3 months
  • Follow-up care will be shared between the transplant center and the referring physician
  • The time frame for disease staging post transplant may vary for specific diseases or research protocols

 

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu