Clinical Research

Clinical research evaluates new laboratory findings that might advance cancer diagnosis, treatment or prevention in human beings. The evaluations are done using studies called clinical trials. The OSUCCC – James hundreds of clinical trials going on at anytime. Many are original studies initiated by OSUCCC – James investigators.

OSUCCC – James Clinical Research Strengths

  • The OSUCCC – James is one of only a few centers nationally funded by the NCI to conduct both phase I and phase II clinical trials.
  • OSUCCC – James investigators have decades of experience designing and conducting phase I and phase II cancer studies.
  • The new James Cancer Hospital and Solove Research Institute incorporates features designed to facilitate and encourage clinical research.
    • Each inpatient floor has translational research labs that bring physicians together with researchers to develop and deliver the most effective targeted therapies for patients
    • A dedicated early-phase Clinical Trials Unit offers a comforting patient environment with a staff highly experienced in safely conducting innovative, early-phase trials.
    • A state-of-the-art, good manufacturing processes Cellular Processing Laboratory supports the hospital’s 36-bed Blood and Marrow Transplant Unit
  • Precision Cancer Medicine at the new James uses advanced genomic technologies to identify the molecular changes that cause a patient’s cancer.
  • The OSUCCC – James is a comprehensive biomedical research campus with strong collaboration between investigators from the Colleges of Medicine, Pharmacy, Public Health, Nursing, Dentistry and Engineering.
  • Every clinical trial at the OSUCCC – James engages a team of scientists and includes near real-time pharmacokinetics, pharmacodynamics and pharmacogenomics correlative studies.
  • OSUCCC – James investigators collaborate extensively with other centers dedicated to experimental therapeutics.
  • After defining the safety profile and clinical characteristics of novel agents, OSUCCC – James investigators pursue development of strategic combination regimens.
  • OSUCCC – James trials often support new drug approvals by the FDA, while many others are hypothesis-driven therapeutic trials. These include trials for molecular-targeted therapies and genomic profiling of patient tumors, and trials to identify predictive biomarkers.
  • Original OSUCCC – James trials include basic scientists who help design the trial and contribute to the discovery of novel therapies.

Breast Cancer

At the OSUCCC – James, a multidisciplinary team of medical, surgical and radiation oncologists, as well as breast reconstruction surgeons and rehabilitation therapists, creates research-based treatment plans tailored to each patient's type of breast cancer.

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CNS Malignancy/Brain and Nervous System

The OSUCCC – James CNS malignancies clinical research program evaluates state-of-the-art therapies for patients with cancer of the central nervous system. Neuro-oncology physician-researchers work closely with translational researchers and basic scientists who specialize in CNS malignancies to rapidly apply research results to patient care.

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Gastrointestinal Cancers

At the OSUCCC – James, highly specialized gastrointestinal oncologists, surgeons, researchers and other experts in this discipline collaborate to turn scientific discoveries into innovative treatments tailored to each patient’s individual cancer.

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Genitourinary Cancers

The genitourinary oncology program at the OSUCCC – James is committed to providing a range of clinical trial opportunities to our patients undergoing care for prostate, bladder, testicular, and kidney cancer.

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Gynecologic Cancers

At the OSUCCC – James, our treatment team is dedicated to providing excellent, research-based clinical care for women who have or are at risk for gynecologic cancer. Working closely together, our physicians and researchers are better able to translate scientific advances to innovative patient care.

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Head and Neck Cancers

The head and neck oncology program at OSUCCC – James is at the forefront of the world’s efforts to improve outcomes of patients with head and neck malignancies. The team’s bench-to-bedside focus consistently offers patients newer, safer and more effective treatments as they are developed.

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Hematologic Malignancies

The OSUCCC – James is home to an internationally renowned center for hematologic malignancy treatment and research. Transdisciplinary teams of hematologists, oncologists, mid-level practitioners, researchers, nurses and other experts specialize in distinct hematologic malignancies.

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Melanoma

The malignant melanoma clinical research program at the OSUCCC – James offers patients access to clinical trials evaluating the newest agents and strategies for preventing, detecting, diagnosing and treating melanoma and other skin cancers.

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Sarcoma

The OSUCCC – James has a history of science-based patient care in adult and pediatric sarcomas. The program encompasses one of the most complete continuum's of sarcoma research and clinical faculty in the United States, featuring experts from Ohio State, Nationwide Children’s Hospital (NCH) in Columbus, and the University’s College of Veterinary Medicine.

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Thoracic

The thoracic cancer program at OSUCCC – James includes medical, surgical and plastic surgery, with radiation oncologists, pathologists, pulmonologists, researchers and other experts focused on prevention, early diagnosis and improved long term outcomes for patients with thoracic cancers. This exceptional team of experts uses multiple treatment modalities to optimize treatment plans for each patient.

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Thyroid/Neuroendocrine

At the OSUCCC – James, experts in this highly specialized field are dedicated to supporting and caring for patients with endocrine cancers and their families. Our team approach provides the best research and science-based treatment, putting our physicians and researchers on the leading edge of advances in detecting and treating these malignancies.

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Nursing Research

The OSUCCC – James nursing philosophy emphasizes our belief that discovery supports evidence-based practice, fosters innovative patient care through research and promotes professional development. The oncology nurses partner with teams of physicians and scientists from across disciplines who take ideas from bench to bedside

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