Chang-hyuk Kwon, PhD
College of Medicine
Molecular Biology and Cancer Genetics
Astrocytoma, Macrocephaly, Disease Models, Animal, Glioma, Hypertrophy, Neurofibromatosis 1, Loss of Heterozygosity
Dr. Kwon's laboratory is studying glioblastoma, the most aggressive and common brain malignancy with poor prognosis. By using Nf1, Trp53 and Pten conditional deletion in the brain, we have generated physiologically relevant mouse genetic models of this devastating disease. We also have demonstrated that a majority of the brain tumor type originates from neural stem cell lineage. By culturing the origin and tumor cells in neurosphere and monitoring molecular and cellular changes during the tumor development, we are searching for tumor drivers responsible for glioblastoma formation.