Ching-Shih Chen, PhD

Ching-Shih Chen

College

College of Pharmacy

Department/Division

Medicinal Chemistry & Pharmacognosy

Academic Title

Professor

Research Program

Molecular Carcinogenesis and Chemoprevention

Research Interest

Prostatic Neoplasms, Neoplasms, Leukemia, Lymphocytic, Chronic, B-Cell, Breast Neoplasms, Disease Models, Animal, Carcinoma, Hepatocellular, Cell Transformation, Neoplastic, Liver Neoplasms

Dr. Chen's research focuses on exploring signaling pathways that govern cancer cell survival as targets for drug discovery and design. He employs a multidisciplinary approach to identify new molecular targets by combining a wide range of expertise encompassing synthetic medicinal chemistry, molecular and cell biology, molecular pharmacology, and animal models in his research team. His laboratory has developed a series of novel small-molecule agents that target different molecular defects related to kinase signaling, epigenetics, and cell metabolism in cancer cells, including phosphoinositide-dependent kinase (PDK)-1/Akt inhibitors, histone deacetylase (HDAC) inhibitors, Bcl-2/Bcl-xL inhibitors, protein kinase C delta activators, AMPK activators, and glucose transporter inhibitors. These novel agents mediate antiproliferative effects through mechanisms distinct from that of conventional chemotherapeutic regimens, which will provide a rational approach for molecular targeted cancer therapy.


Education and Background

Office Location

336 Parks Hall

500 W 12th Avenue, Columbus, Ohio 43210


614-688-4008

614-688-8556



Publications

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