F. Kay Huebner, PhD

F. Kay Huebner

College

College of Medicine

Division/Department

Molecular Virology, Immunology & Medical Genetics

Academic Title

Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Neoplasms, Chromosome Fragility, Cell Transformation, Neoplastic, Loss of Heterozygosity, Chromosome Deletion, Kidney Neoplasms, DNA Damage, Breast Neoplasms, Genetic Markers, Esophageal Neoplasms

 The major focus of the laboratory is to thoroughly investigate and define the biological functions of the tumor suppressor proteins, Fhit and Wwox, encoded by the chromosome fragile sites FRA3B and FRA16D, two of the most frequently inactivated tumor suppressors in a broad spectrum of human cancers. The biological functions of the two proteins are studied using the full panoply of molecular genetic techniques in in vitro and in vivo models. Tumor suppressor related changes defined in tissue culture or mouse models are quickly examined also in human tissues from anonymous human cancers in order to confirm the laboratory findings in actual human cancers of breast, pancreas and other cancers, with the ultimate goal of identifying  prognostically useful protein markers and possible therapeutic targets for specific cancers.


Education and Background

Office Locations

916 Biomedical Research Tower

460 W 12th Avenue, Columbus, Ohio 43210


614-292-4850

614-292-3312



Publications

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