F. Kay Huebner, PhD
College of Medicine
Molecular Virology, Immunology & Medical Genetics
Molecular Biology and Cancer Genetics
Chromosome Fragility, Cell Transformation, Neoplastic, Loss of Heterozygosity, Chromosome Deletion, Kidney Neoplasms, DNA Damage, Genetic Markers, Esophageal Neoplasms, Carcinoma, Renal Cell
The major focus of the laboratory is to thoroughly investigate and define the biological functions of the tumor suppressor proteins, Fhit and Wwox, encoded by the chromosome fragile sites FRA3B and FRA16D, two of the most frequently inactivated tumor suppressors in a broad spectrum of human cancers. The biological functions of the two proteins are studied using the full panoply of molecular genetic techniques in in vitro and in vivo models. Tumor suppressor related changes defined in tissue culture or mouse models are quickly examined also in human tissues from anonymous human cancers in order to confirm the laboratory findings in actual human cancers of breast, pancreas and other cancers, with the ultimate goal of identifying prognostically useful protein markers and possible therapeutic targets for specific cancers.