Harold A Fisk, PhD, Affiliate
College of Arts & Sciences
Molecular Genetics / Molecular Genetics Admin
Molecular Biology and Cancer Genetics
Leukemia, Large Granular Lymphocytic, Mammary Neoplasms, Experimental, Neoplasms, Cell Transformation, Neoplastic
Centrosomes are microtubule-organizing structures that coordinate mitotic spindle assembly and chromosome segregation. Centrosome aberrations are found in a variety of tumors, and are associated with tumorigenesis in breast cancer, prostate cancer, and leukemia. Centrosome duplication is controlled by the Mps1 protein kinase, and misregulation of Mps1 correlates with both centrosome aberrations and tumorigenesis. I have identified an Mps1 mutation that causes centrosome aberrations. My research program will investigate the function of Mps1 in centrosome duplication, the contribution of Mps1 to centrosome aberrations in human tumors, and the contribution of Mps1 dysfunction to centrosome defects and tumorigenesis.