John S Gunn, PhD, Affiliate
College of Medicine
Molecular Virology, Immunology & Medical Genetics
Molecular Biology and Cancer Genetics
Tularemia, Gram-Negative Bacterial Infections, Salmonella Infections, Animal, Infection, Salmonella Infections, Typhoid Fever, Carrier State, Mutagenesis, Insertional
My laboratory performs research pertaining to microbial resistance to innate Immunity. Much of our research is focused on the macrophage, as well as the mucosal surface. We are interested in microbial (Salmonella/Francisella) mechanisms of resistance to innate immune components (i.e. antimicrobial peptides) and to killing by host phagocytes. In addition, we study Salmonella chronic carriage, which occurs in the human gallbladder and is associated with the presence of gallstones. Chronic carriage is linked to an increased risk of gallbladder/ hepatobiliary carcinoma. We are examining this in a mouse model. Discerning whether S. Typhi gallbladder carriage leads to cancer could significantly contribute to the early detection and/or prevention of gallbladder cancer. Further, this study will provide scientific evidence for the broader relationship between chronic infections and cancer.