Michael A Pereira, PhD, Affiliate
College of Medicine
Molecular Carcinogenesis and Chemoprevention
Liver Neoplasms, Experimental, Neoplasms, Colonic Neoplasms, Adenoma, Lung Neoplasms, Cocarcinogenesis, Aberrant Crypt Foci, Liver Neoplasms, Adenocarcinoma, Disease Models, Animal
Current research involves identification of new chemopreventive agents, and determination of their efficacy and mechanism of action. The identification and determination of the efficacy of new chemopreventive agents has focused on drugs including NSAIDs, retinoids, and HDAC inhibitors. The efficacy studies have also focused on the use of combinations of chemopreventive agents administered either together or sequentially. The mechanism studies are determining the mechanism by which chemopreventive agents slow the progression to cancer. These studies have mainly investigated epigenetic mechanisms.