Qi-En Wang, PhD
College of Medicine
Molecular Carcinogenesis and Chemoprevention
DNA Damage, Ovarian Neoplasms, Li-Fraumeni Syndrome, Xeroderma Pigmentosum, Adenocarcinoma, Carcinoma, Papillary, Glioblastoma
The focus of Dr. Wang's research is on the regulation of nucleotide excision repair (NER), one of the DNA repair pathways, and the connection of DNA repair to cancer therapy. Dr. Wang's research strives to explore the mechanism of NER, and finally find means to prevent cancer initiation via improving normal cells’ capability to repair DNA damage or to enhance the efficacy of cancer therapy through inhibiting the repair of DNA damage induced by chemotherapeutic agents and radiotherapy. Three separate projects are being pursued: Chromatin modification and remodeling in NER following UV or cisplatin treatment; Protein posttranslational modifications and degradation in DNA repair; and Role of NER proteins in chemotherapeutic agents-induced apoptosis.