Qianben Wang, PhD

Qianben Wang

College

College of Medicine

Division/Department

Molecular & Cellular Biochemistry

Academic Title

Assoc Professor

Research Program

Molecular Carcinogenesis and Chemoprevention

Research Interest

Prostatic Neoplasms, Neoplasms, Hormone-Dependent, Breast Neoplasms, Neoplasms, Carney Complex, Adenocarcinoma

Dr. Wang's laboratory is interested in understanding the role of androgen receptor (AR) in the development and progression of prostate cancer. AR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily. The application of chromatin immunoprecipitation (ChIP) to study protein-DNA interaction has provided a wealth of information on temporal and spatial assembly of AR transcription complex on target gene regulatory regions in vivo. However, studying of only a few target genes by ChIP greatly limits our understanding of how AR regulates target gene network. The recent development of the ChIP-on-chip (ChIP on a microarray) or ChIP-seq (ChIP combined with high throughput sequencing) technique allows the global identification of specific transcription factor regulatory regions across the human genome. They have mapped AR binding regions in the entire human genome in both androgen-dependent prostate cancer (ADPC) and androgen-independent prostate cancer (AIPC).


Education and Background

Office Locations

888 Biomedical Research Tower

460 W 12th Avenue, Columbus, Ohio 43210


614-247-1609



Publications

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