Richard S Bruno, PhD, RD
College of Education & Human Ecology
Molecular Carcinogenesis and Chemoprevention
The biochemical and molecular nutrition research conducted in Dr. Bruno’s laboratory aims to define the mechanisms regulating the bioavailability of dietary phytochemicals, particularly polyphenols such as quercetin and antioxidants including vitamin E, and the mechanisms by which these dietary agents protect against oxidative stress and pro-inflammatory responses that otherwise contribute to liver cancer resulting from nonalcoholic steatohepatitis (NASH). His work routinely utilizes model systems recapitulating oxidative stress and inflammatory responses observed in humans with the underlying goal of translating experimental findings into practical recommendations that promote optimal health. The research of his laboratory is currently directed at: 1) conducting vitamin E pharmacokinetic studies to define fractional turnover of a-tocopherol in patients with metabolic syndrome in order to better define dietary vitamin E requirements in populations having a high inflammatory burden, 2) validating nano-emulsion based delivery systems of polyphenols to enhance their bioavailability and putative bioactivity, and 3) defining Nrf2-dependent cytoprotective responses regulated by green tea that suppress hepatic NF?B-dependent pro-inflammatory responses that otherwise lead to hepatocellular injury implicated in liver cancer.