Richard A Fishel, PhD
College of Medicine
Molecular Virology, Immunology & Medical Genetics
Molecular Biology and Cancer Genetics
Colorectal Neoplasms, Hereditary Nonpolyposis, Base Pair Mismatch, Microsatellite Instability, Colorectal Neoplasms, DNA Damage, Cell Transformation, Neoplastic, Colonic Neoplasms, Loss of Heterozygosity
Dr Fishel’s research interests includes DNA Repair defects and Genomic Instability in cancer development; biophysical chemistry of DNA repair; and single molecule imaging in vitro and in vivo. His laboratory studies the mechanisms, genetics, regulation, and consequences of DNA repair and genome rearrangement in human cells. Dr. Fishel was one of the principle discoverers of the human mismatch repair genes and their role in hereditary and sporadic cancers. His research utilizes fundamental biophysical methods (surface plasmon resonance, stop flow/quench flow kinetics, fluorescent anisotropy, single molecule analysis, etc.), genetic analysis, and includes genome engineering of mutations/gene-fusions in human cells using CRISPR technologies. Dr. Fishel has also developed mismatch repair defective mouse models of cancer to examine cancer development and cancer chemoprevention.