Thomas J Rosol, DVM, PhD

Thomas Rosol

College

College of Veterinary Medicine

Division/Department

Veterinary Biosciences

Academic Title

Professor

Research Program

Molecular Carcinogenesis and Chemoprevention

Research Interest

Dog Diseases, Bone Neoplasms, Prostatic Neoplasms, Disease Models, Animal, Carcinoma, Squamous Cell, Neoplasm Metastasis, Lung Neoplasms, Horse Diseases, Leukemia-Lymphoma, Adult T-Cell, Osteolysis

Dr. Rosol's Laboratory is NCI and NCRR-funded to develop mouse models of human cancer with emphasis on bone metastasis, bone resorption and formation, and cancer-associated hypercalcemia. The molecular regulation of parathyroid hormone-related protein (PTHrP) is studied in vitro and in vivo using animal models of prostate, lung, breast, and head & neck cancer, and lymphoma and PTHrP knockout mice. Both breast and prostate cancer metastasize to bone in humans, but breast cancer typically induces osteolytic disease and prostate cancer typically induces osteoblastic metastases. The Rosol lab has developed mouse models of breast and prostate cancer that mimic the metastases in humans and are used to investigate the pathogenesis and treatment of metastasis. Models of metastasis include intracardiac, intratibial, and orthotopic injections of tumor cells. The lab is also collaborating to examine the ability of nanoparticles to enhance the ultrasound imaging of cancer molecular markers. 


Education and Background

Office Locations

307 Goss Laboratory

1925 Coffey Road, Columbus, Ohio 43210


614-292-4265

614-292-6473



Publications

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