Traci A Wilgus, PhD
College of Medicine
Molecular Carcinogenesis and Chemoprevention
Inflammation, Wounds and Injuries, Skin Neoplasms, Dermatitis, Neoplasms, Neoplasms, Radiation-Induced, Disease Models, Animal, Fibrosis, Prenatal Injuries, Sunburn
Dr. Wilgus studies the involvement of the pro-angiogenic growth factor vascular endothelial growth factor (VEGF) in skin carcinogenesis. VEGF is known to contribute to skin carcinogenesis by enhancing angiogenesis. Her lab has found that VEGFR-1 (VEGF receptor-1) is expressed by normal epidermal keratinocytes and tumor cells from non-melanoma skin cancers. Studies are underway to determine whether VEGF can directly influence these cells by signaling through VEGFR-1, and the potential importance of epithelial VEGFR-1 signaling for the growth and development of skin tumors.