Fen Xia, MD, PhD

Fen Xia

College

College of Medicine

Department/Division

Radiation Oncology

Academic Title

Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

DNA Breaks, Double-Stranded, DNA Damage, Breast Neoplasms, Neoplasms, Pancreatic Neoplasms, Glioma, Sequence Deletion, Melanoma, Oxidative stress, Adenocarcinoma

Research in the Xia laboratory focuses on elucidating the mechanisms that regulate the repair of chromosomal double-strand breaks (DSB) that arise during physiological DNA metabolism and after radiation therapy or chemotherapy. We aim to understand 1) the impact of deregulated DSB repair on carcinogenesis and the development of tumor resistance to therapy and 2) to explore novel avenues of cancer treatment targeting the DSB repair pathways. We have developed an array of intrachromosomal and extrachromosomal repair substrates that allow analysis of the quantity and quality of DSB repair by different mechanisms in mammalian cells. An understanding of the defects of DNA repair and its interplay with cell death within tumors; as well as the crosstalk between tumor cell DNA replication/repair process with its microenvironment may offer novel avenues for both cancer prevention and tailored therapy.


Education and Background

Education

  • MD, Suzhou Medical College

    China (China)

Fellowship

  • Research Fellow in Department of Aging

    Harvard Medical School

    Boston, MA (USA)

  • Research Fellow in Department of Cancer Cell Biology

    Harvard University School of Public Health

    Boston, MA (USA)

  • Research Fellow in Department of Cancer Cell Biology

    Harvard University School of Public Health

    Boston, MA (USA)

Office Location

Tzagournis Med Res Facility

420 W 12th Avenue, Columbus, Ohio 43210


614-293-8415



Publications

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