Harold Fisk, PhD, Affiliate

Harold Fisk

College

College of Arts & Sciences

Department/Division

Molecular Genetics / Molecular Genetics Admin

Academic Title

Assoc Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Leukemia, Large Granular Lymphocytic, Mammary Neoplasms, Experimental, Cell Transformation, Neoplastic, Neoplasms

 Centrosomes are microtubule-organizing structures that coordinate mitotic spindle assembly and chromosome segregation. Centrosome aberrations are found in a variety of tumors, and are associated with tumorigenesis in breast cancer, prostate cancer, and leukemia. Centrosome duplication is controlled by the Mps1 protein kinase, and misregulation of Mps1 correlates with both centrosome aberrations and tumorigenesis. I have identified an Mps1 mutation that causes centrosome aberrations. My research program will investigate the function of Mps1 in centrosome duplication, the contribution of Mps1 to centrosome aberrations in human tumors, and the contribution of Mps1 dysfunction to centrosome defects and tumorigenesis.


Education and Background

Office Location

216 Bioscience Building

484 W 12th Avenue, Columbus, Ohio 43210


614-292-0318

614-292-4466



Publications

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