Ioanna Papandreou, PhD

Ioanna Papandreou

College

College of Medicine

Department/Division

Radiation Oncology

Academic Title

Res Asst Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Anoxia, Neoplasms, Endoplasmic Reticulum Stress, Oxidative stress, Fatty Liver, Alcoholic, Melanoma, Experimental, Fibrosarcoma, Mammary Neoplasms, Experimental, Neovascularization, Pathologic, Multiple Myeloma

The dysfunctional tumor vasculature and the deregulated cancer cell proliferation create areas of oxygen- and nutrient- deprivation in solid tumors. Cells within the tumor respond to these microenvironmental stresses by activating adaptive mechanisms that allow malignant progression under such harsh conditions. Dr. Papandreou is investigating stress-modulated transcriptional and biochemical pathways, with particular emphasis given to the reprogramming of glucose and lipid metabolism under hypoxic environments. Her research employs in vitro models of hypoxia and hypoglycemia, tumor xenotransplantation protocols and genetically engineered mouse models with the goal to identify new targets for therapeutic development.


Education and Background

Office Location

324 Tzagournis Med Res Facility

420 W 12th Avenue, Columbus, Ohio 43210




Publications

Back to Researcher Search