Qianben Wang, PhD
College of Medicine
Molecular & Cellular Biochemistry
Molecular Carcinogenesis and Chemoprevention
Dr. Wang's laboratory is interested in understanding the role of androgen receptor (AR) in the development and progression of prostate cancer. AR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily. The application of chromatin immunoprecipitation (ChIP) to study protein-DNA interaction has provided a wealth of information on temporal and spatial assembly of AR transcription complex on target gene regulatory regions in vivo. However, studying of only a few target genes by ChIP greatly limits our understanding of how AR regulates target gene network. The recent development of the ChIP-on-chip (ChIP on a microarray) or ChIP-seq (ChIP combined with high throughput sequencing) technique allows the global identification of specific transcription factor regulatory regions across the human genome. They have mapped AR binding regions in the entire human genome in both androgen-dependent prostate cancer (ADPC) and androgen-independent prostate cancer (AIPC).