Yuri Pekarsky, PhD, Affiliate

Yuri Pekarsky

College

College of Medicine

Department/Division

Molecular Virology, Immunology & Medical Genetics

Academic Title

Res Asst Professor

Research Program

Molecular Biology and Cancer Genetics

Research Interest

Leukemia, Lymphocytic, Chronic, B-Cell, Leukemia, T-Cell, Neoplasms, Leukemia, Disease Models, Animal, Lymphoma, T-Cell, Chromosome Aberrations, Cell Transformation, Neoplastic, Trisomy, Lung Neoplasms

Mature T-cell leukemia commonly shows chromosomal rearrangements at 14q32.1 including translocations t(14;14)(q11;q32), t(7;14)(q35;q32) and inversions inv(14)(q11;q32). The investigation of the locus in question at 14q32.1 resulted in the identification of two related genes named TCL1 and TCL1b. Both genes are activated in T-PLL/T-CLL by the chromosomal aberrations mentioned above. Recently we discovered that biochemically, TCL1 works as a co-factor of the Akt kinase, a key regulator of antiapoptotic and proliferative signals. Tcl1 interacts physically with Akt, increases its kinase activity and facilitates its transport to the nucleus. The pathogenesis of T-PLL/T-CLL may also involve Nur77, a T-cell transcription factor required for T-cell receptor (TCR) mediated apoptosis. In our recent publication we demonstrate that Akt phosphorylates Nur77, thereby blocking its DNA-binding ability and rendering the transcription factor inactive. Currently we concentrate on studying of downstream events of this pathway as well as on the identification new pathways involving Tcl1 and Akt.


Education and Background

Office Location

1090 Biomedical Research Tower

460 W 12th Avenue, Columbus, Ohio 43210


614-292-4134



Publications

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