BACKGROUND : Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator in cancer cell survival, epithelial-mesenchymal transition, and tumorigenesis. Inhibition of EZH2 has become a promising therapeutic option for various human malignancies. Previously, we... Read More
Interaction of endothelial-lineage cells with three-dimensional substrates was much less studied than that with flat culture surfaces. We investigated the in vitro attachment of both mature endothelial cells (ECs) and of less differentiated EC colony-forming cells to... Read More
This article considers the practical problem in clinical and observational studies where multiple treatment or prognostic groups are compared and the observed survival data are subject to right censoring. Two possible formulations of multiple comparisons are... Read More
BACKGROUND : Data for multiple common susceptibility alleles for breast cancer may be combined to identify women at different levels of breast cancer risk. Such stratification could guide preventive and screening strategies. However, empirical evidence for genetic... Read More
Recurrent meningiomas constitute an uncommon but significant problem after standard (surgery and radiation) therapy failure. Current chemotherapies (hydroxyurea, RU-486, and interferon-a) are only of marginal benefit. There is an urgent need for more effective... Read More
The tumorigenic potential of dulaglutide was evaluated in rats and transgenic mice. Rats were injected subcutaneously twice weekly for 93 weeks with dulaglutide 0, 0.05, 0.5, 1.5, or 5 mg/kg corresponding to 0, 0.5, 7, 20, and 58 times, respectively, the maximum... Read More
Positive detection of minimal residual disease (MRD) by multichannel flow cytometry (MFC) prior to hematopoietic cell transplantation (HCT) of patients with ALL identifies patients at high risk for relapse, but many pre-HCT MFC-MRD negative patients also relapse, and... Read More
Glucagon-like peptide-1 (GLP-1) receptor agonists, used for treatment of type 2 diabetes, have caused hyperplasia/neoplasia of thyroid C-cells in rodent carcinogenicity studies. Studies in monkeys have not identified an effect of GLP-1 receptor agonists on thyroid... Read More
Germ-line mutations in MLH1, MSH2, MSH6, and PMS2 have been shown to cause Lynch syndrome. The penetrance of the cancer and tumor spectrum has been repeatedly studied, and multiple professional societies have proposed clinical management guidelines for affected... Read More
High prevalence of tobacco use and low success in quitting remain significant problems for reducing disease burden among HIV-infected persons. This study's purpose was to examine participant responsiveness and tobacco dependence treatment adherence and their... Read More
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April 16, 2015
In this week’s Toward a Cancer-Free World, OSUCCC – James skin cancer expert Dr. Kari Kendra tells us why today’s advances in melanoma research and treatment offer even greater hope to skin cancer...
April 15, 2015
This is the first of a new series of blog posts to feature a recipe from OSUCCC - James Chef Renee Bean. Her barley and split pea soup with kale and sweet potato is not only delicious, but also...
April 10, 2015
The new James Cancer Hospital and Solove Research Institute includes a ramped-up Cell Therapy Laboratory (CTL) that can produce clinical-grade living cells for use in immune therapy research.