BACKGROUND : Enhancer of zeste homolog 2 (EZH2) is a key epigenetic regulator in cancer cell survival, epithelial-mesenchymal transition, and tumorigenesis. Inhibition of EZH2 has become a promising therapeutic option for various human malignancies. Previously, we... Read More
The etiologic contribution of germline genetic variation to sporadic osteosarcoma is not well understood. Osteosarcoma is a sentinel cancer of Li-Fraumeni syndrome (LFS), in which approximately 70% of families meeting the classic criteria have germline TP53 mutations... Read More
Interaction of endothelial-lineage cells with three-dimensional substrates was much less studied than that with flat culture surfaces. We investigated the in vitro attachment of both mature endothelial cells (ECs) and of less differentiated EC colony-forming cells to... Read More
This article considers the practical problem in clinical and observational studies where multiple treatment or prognostic groups are compared and the observed survival data are subject to right censoring. Two possible formulations of multiple comparisons are... Read More
OBJECTIVES : Objectives of this study were to examine the constructs of the Theory of Planned Behavior and determine how they predict Lebanese medical students' behavioral intention to advise patients to quit smoking.STUDY DESIGN : This was a cross-sectional study... Read More
Ibrutinib has significantly improved the outcome of patients with relapsed chronic lymphocytic leukemia (CLL). Recent reports attribute ibrutinib resistance to acquired mutations in Bruton agammaglobulinemia tyrosine kinase (BTK), the target of ibrutinib, as well as... Read More
Colorectal cancer (CRC) can be classified into different types. Chromosomal instable (CIN) colon cancers are thought to be the most common type of colon cancer. The risk of developing a CIN-related CRC is due in part to inherited risk factors. Genome-wide association... Read More
PURPOSE : We examined patient- and provider-level factors associated with initiation of three adolescent immunizations among 13 to 18 year olds in an adolescent primary care clinic.METHODS : Data were extracted retrospectively from medical records. Logistic regression... Read More
PURPOSE : Cancer screening strategies have commonly adopted single-biomarker thresholds to identify abnormality. We investigated the impact of serial biomarker change interpreted through a risk algorithm on cancer detection rates.PATIENTS AND METHODS : In the United... Read More
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May 22, 2015
Experts at The James found in a recent study that practicing yoga for as little as just three months can actually help reduce fatigue and lower inflammation in breast cancer survivors.
May 19, 2015
Jamine Waggle, Cancer Survivor and I Ride for You participant, shares how Pelotonia and the I Ride for You program helped her find purpose in her cancer diagnosis.
May 14, 2015
The Statue of Hope, a symbol of hope and inspiration for patients, medical experts and visitors to The James, received a formal welcome and dedication this week in front of the new James Cancer Hospital.