Leona W. Ayers, MD, manages the Ayers Lab. Research focuses on these areas:

Biospecimens and Biorepositories

Dr. Ayers is principal investigator of the Midwestern Division of the Collaborative (formerly Cooperative) Human Tissue Network (CHTN), which is managed from her lab.

The Collaborative Human Tissue Network (CHTN) is a national research tissue procurement group that assists translational investigators in both the academic and commercial research setting with emphasis on cancer research. National Cancer Institute (NCI)-funded investigators receive priority for service through this group.

The Midwestern Division of CHTN (MW CHTN) is located at The Ohio State University and has been granted funds from the NCI/NIH to distribute prospectively procured, investigator-defined, high-quality surgical remnant pre-malignant, malignant, benign, diseased and normal biospecimens to funded, IRB-approved investigators. This research service is subsidized but not fully supported by the NCI grant. A small fee set by the national CHTN and the NCI is collected from investigators to supplement the cost of specimen procurement.

Biospecimens are procured for the MW CHTN-supported investigators by the Research Tissue Procurement Service (RTPS) of the Department of Pathology/Human Tissue Research Network (HTRN). The MW CHTN disbursed 49,372 high-quality biospecimens with associated limited data sets to 924 investigators from 2008 to 2012. The national CHTN (five divisions) has disbursed over 1 million biosamples since the initiation of this NCI-supported program in 1987.

Individual research consultation and additional laboratory services are available to interested investigators or investigators who need assistance at any time during their research protocol development and deployment.

The Midwestern Division also works with the NCI and other CHTN divisions to advance biospecimen science, as well as to improve data management and the availability of quality biospecimens for cutting-edge translational research.

Tissue Feature Quantification Using Digital Image Analysis

Tissue features can be specifically stained in mounted tissue sections, digitized and quantified using tissue morphometric software such as Definiens Tissue Studio. Quantified results can replace visual imprecise qualitative assessments. The Ayers Lab has helped investigators use this software-based approach to quantify tissue vascular density, cell types in tissue, nuclear size and other features.

HIV/AIDS-Related Lymphoma

Dr. Ayers was principal investigator of the AIDS and Cancer Specimen Resource (ACSR), 1995-2014, and Sub-Saharan Africa Lymphoma Consortium (SSALC/ACSR), 2007-2014. She participated in NCI clinical trial: Epidemiology of Burkitt Lymphoma in East Africa Children or Minors (EMBLEM).

Contact Us

Ayers Lab
Innovation Centre
2001 Polaris Parkway
Columbus, OH 43240
Phone: 614-293-8106
Email: ayers.1@osu.edu

CCC Members

Don Benson, MD, PhD

Our laboratory and clinical research programs seek to develop novel treatments for cancer that harness and enhance the immune system’s ability to detect and kill cancer cells. Natural killer cells, one type of immune cell in the body, are capable of killing cancer cells and much of the research.

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Michael Caligiuri, MD

The Caligiuri laboratory has three areas of interest. First is to understand the development and normal role of the body's large granular lymphocytes called natural killer cells , and to exploit their properties in order to develop effective therapies against cancer and immune deficiency.

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Anjali Mishra, PhD

Dr. Mishra's research has shown stage-related ‘interleukin-15 (IL-15)’ mRNA and protein over-expression in lesional skin and circulating tumor cells of CTCL patients. Using IL-15 transgenic (tg) mice, Dr. Mishra's lab has characterized an animal model of spontaneous epidermotropic T-cell lymphoma.

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Jianhua Yu, PhD

Dr. Yu's research interests include Immuno-cellular therapy, blood and marrow transplantation, NK cell biology, gene regulation and cell signaling in immune response and malignant transformation

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Researchers

Donna Bucci, BS

Donna serves as Manager of the Caligiuri Research Lab, HEME Biorepositories and OSU Leukemia Tissue Bank Shared Resource.

Wing Chan, PhD

Wing recently joined the Caligiuri Lab as a Post-Doctoral Researcher. He came to the lab from St. Jude’s Research Center. Wing works with the NK Cell Development and Oncolytic Virus Research Teams.

Li Chen, MB

Li is a Research Associate in the Caligiuri Lab. Li works with the NK Cell Development team.

HongSheng Dai, PhD

HongSheng is a Post-Doctoral Fellow and recipient of a Pelotonia Fellowship for 2014-2016. HongSheng works with the NK Cell Development and Oncolytic Virus Research Teams.

Christopher Manring, BA

Chris is the Research Data Manager for the HEME Biorepository and OSU Leukemia Tissue Bank Shared Resource.

Charlene Mao, MS

Charlene serves as Research Associate and Flow Cytometry Specialist in the Caligiuri Lab. Charlene plays a key role in the lab providing training and support for all research teams.

Kathleen McConnell, BS

Kathleen serves as Research Assistant and Research Animal Colony Specialist in the Caligiuri Lab. Kathleen plays a key role in the lab providing training and support for all research teams.

Bethany Mundy-Bosse, PhD

Bethany studies Natural Killer (NK) cell development related to Acute Myeloid Leukemia and is a recipient of the prestigious T32 Post-Doctoral Fellowship award for training in Oncology.

Il-Kyoo Park, PhD

Il-Kyoo studies NK cell development related to Acute Myeloid Leukemia and is a recipient of the prestigious T32 Post-Doctoral Fellowship award for training in Oncology.

Victoria Sellers, BS

Victoria serves as Research Assistant and Research Animal Colony Specialist in the Caligiuri Lab. Victoria primarily supports NK Cell Development projects.

Robin Taxier, BS

Robin is Research Technologist for the OSU Leukemia Tissue Bank Shared Resource and Alliance HEME Biorepository.

Wacharaphon Vonchucherd, BS

Wacharaphon is the Senior Research Technologist for the OSU Leukemia Tissue Bank Shared Resource and Alliance HEME Biorepository.

Jing Wen, MB

Jing is a Research Associate with the Mishra Lab research team.

Max Yano, AB

Max is Research Aide with the Mishra Lab research team.

Students

Elshafa Ahmed , CVM, MPH

Elshafa is currently pursuing a PhD in Veterinary Biosciences; Dr. Caligiuri is her Doctoral Advisor. She is studying the development of vaccine for a specific type of tumor relevant to post organ transplant disease.

Stephen Bergin, BS

Stephen is enrolled in the MD/PhD program, OSU School of Medicine. Stephen works with the NK Cell Development and Oncolytic Virus Research Teams.

Daniel Brook

Daniel is an undergraduate student at OSU and Research Volunteer in the Caligiuri lab.

Billy Carson

Billy is an undergraduate student at OSU and a Wells Family Scholar for 2014.

Taylor Fisher

Taylor is an undergraduate student at OSU and a Student Clinical Data Assistant for the OSU Leukemia Tissue Bank Shared Resource.

Erin Glankler

Erin is an undergraduate student at OSU and a Research Volunteer working in the Wing Chan lab.

Nathaniel Griffin

Nathaniel is an OSU Undergraduate Research Volunteer working with Hongsheng Dai.

Evan Gutter

Evan is an undergraduate student at OSU and a Research Volunteer working in the Biorepository Central Processing Lab.

Sonya Kwiatkowski

Sonya is an Undergraduate Research Assistant. Sonya works with the Mishra Lab research team.

Ayako McGregor

Ayako is an undergraduate student at OSU and a Student Research Assistant working in the Biorepository Central Processing Lab.

Mary Nemer

Mary is an OSU Undergraduate Research Volunteer working with Aaron Victor.

Steven Scoville, BS

Steven is enrolled in the MD/PhD program, OSU School of Medicine. Steven works with the NK Cell Development team.

Kevin Stephenoff

Kevin is an undergraduate student at OSU and Student Research Assistant working in the Biorepository Central Processing Lab.

Aaron Victor, BS

Aaron is enrolled MD/PhD program, OSU School of Medicine. Aaron works with the NK Development team.


Publications

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