Dr. Roychowdhury is a physician-scientist in medical oncology who focuses on translational cancer genomics and implementing precision cancer medicine. His clinical practice includes patients with advanced metastatic cancer, including prostate, colorectal and rare cancer subtypes.
The overarching goals of the lab include:
- Utilizing genomic testing strategies for patients with advanced cancer
- Identifying the right drug(s) and trials for patients with advanced cancer using genomic testing
- Identifying and studying predictive genomic biomarkers for targeted therapies
- Conducting genomics or mutation-based clinical trials
- Elucidating primary and secondary resistance mechanisms for targeted therapies.
This includes a CLIA grade Cancer Genomics Laboratory for validated and targeted genomic assays, and for research-grade analyses whole-exome/RNA sequencing.
The lab runs a clinical study, “OSU-13053 Precision Cancer Medicine Through High-Throughout Sequencing,” that evaluates patients with advanced cancer who are considering clinical trials and seeks to identify “driving” mutations that provide molecular eligibility for novel molecularly targeted therapies being developed at Ohio State. We are studying the development of primary and secondary resistance for targeted therapies against activating genomic alterations in pathways, including AR, FGFR, BRAF, PI3Kinase and others, through preclinical models and sequential samples from clinical trials.
Sameek Roychowdhury, MD, PhD
Department of Internal Medicine, Division of Medical Oncology
Department of Pharmacology
Comprehensive Cancer Center, The Ohio State University
460 West 12th Avenue
Biomedical Research Tower, Room 508
Columbus, Ohio 43210
Brianna Hunstad – administrative assistant
Darshna Bhatt - laboratory supervisor
Jharna Datta PhD - research scientist
Benjamin Jewell - research assistant
Juliana Lippus - research assistant
Eric Samorodnitsky PhD – postdoctoral fellow- bioinformatics
Jharna Miya - bioinformatics specialist
Julie Reeser PhD – clinical research coordinator
Michele Wing PhD – graduate student