The Ohio Colorectal Cancer Prevention Initiative, led by Heather Hampel ((link to researcher bio)), is a statewide initiative to screen newly diagnosed colorectal cancer patients and their biological relatives for Lynch Syndrome, the most common form of inherited colorectal, ovarian and uterine cancer. The effort – made possible through money raised by Pelotonia – will identify family members who may be at risk of developing these cancers so they can take precautionary measures.Approximately 3 percent of colorectal cancer cases result from Lynch Syndrome, which is characterized by inherited mutations in one of four genes for DNA-repair proteins. Each colorectal cancer patient with Lynch Syndrome has, on average, three relatives with the syndrome, heightening their risk for colorectal cancer.
Based in large part on research conducted at the OSUCCC – James from 1999-2008, the Centers for Disease Control’s Evaluation of Genomic Applications in Practice and Prevention working group recommends that all newly diagnosed colorectal cancer patients be screened for Lynch Syndrome. The OSUCCC – James has done this since 2006 to help reduce morbidity and mortality in colorectal cancer patients and their at-risk relatives, who can also benefit from increased surveillance methods if they too are found to have Lynch Syndrome.
The Ohio Colorectal Cancer Prevention Initiative includes 42 hospitals throughout Ohio that will implement the Lynch Syndrome screening program at their own institutions. They will advise patients and their physicians of the results, offer genetic counseling and make high-risk cancer surveillance recommendations to patients and family members found to have Lynch Syndrome.
It is estimated that the Ohio Colorectal Cancer Prevention Initiative will save nearly 1,000 years of life among Ohioans.
And to prevent ovarian and uterine cancers, women with Lynch Syndrome may choose to have a hysterectomy including removal of their ovaries once they are finished having children.