Meet the leaders and members of the Molecular Biology and Cancer Genetics research program at the OSUCCC – James who promote improved screening, diagnosis, prognosis and treatment.

Leaders

Michael Ostrowski, PhD

Dr. Ostrowski’s lab focuses on understanding interactions between signaling pathways located in the different cell types involved in complex biological processes of cancer cell progression and normal cellular differentiation. For example, a breast tumor is composed not only of the epithelial.

Read More

Matthew Ringel, MD

Dr. Ringel's research interests include molecular mechanisms involved in thyroid cancer invasion and metastasis; with an active interest in new drug testing for thyroid cancer therapy.

Read More

Members

Mohamed Abdel-Rahman, MD, PhD, Affiliate

Dr. Abdel-Rahman's research interests include uveal melanomas, ocular genetics, clinical cancer genetics and ocular pathology.

Read More

Rene Anand, MS, PhD, Affiliate

Dr. Anand's laboratory is interested in understanding how addictive drugs progessively alter the molecular and cellular make up of specific neural circuits to sustain the development of compulsive addictive behavior. They are focused on the actions of nicotine as a model for understanding.

Read More

Paul Andreassen, PhD, Affiliate

Research in the Andreassen Laboratory at Cincinnati Children’s Hospital Medical Center focuses on the relationship of DNA repair and cell cycle checkpoints to the genetic instability that underlies the development of cancer. In particular, we are studying basic cellular mechanisms that respond to.

Read More

Rami Aqeilan, PhD, Affiliate

Dr. Aqeilan studies the molecular aspect of cancer biology aims to uncover the genes (coding and non-coding) that contribute to transforming an incipient cell. Genes, tumor suppressors or oncogenes, are key players in this process.

Read More

Bruce Aronow, PhD

Dr. Aronow's research efforts are directed to the goal of bringing complete knowledge of gene functions and gene activity to the analysis disease mechanisms.  To do this he works with investigators in many different areas of research to use technologies that measure gene activity and gene

Read More

John Barnard, MD, Affiliate

Dr. Barnard is a nationally recognized expert in the biology of transforming growth factor beta the gastrointestinal epithelium and pediatric gastrointestinal polyp disorders.

Read More

Christin Burd, PhD

The INK4/ARF locus encodes three tumor suppressor genes frequently lost or silenced in human cancers (p15INK4b, p16INK4a, and p14ARF). Dr. Burd's lab aims to faithfully recapitulate the genetics of these tumors through the development of genetically engineered mouse models.

Read More

Hakan Cam, PhD, Affiliate

Cancer is a genetic disorder caused by mutations in genes critically involved in the control of cell proliferation. Long-lived organisms, such as humans, have evolved strategies to restrict the development of potentially malignant cells.

Read More

Lei Cao, PhD

Dr. Cao’s lab has characterized a novel brain-fat axis (hypothalamic-sympathoneural-adipocyte axis) underlying the anti-obesity and anticancer phenotypes associated with a complex environment using multidisciplinary approaches to further define this neuroendocrine axis, identify molecular

Read More

Colleen Cebulla, MD, PhD, Affiliate

In addition to seeing patients, Dr. Cebulla is actively engaged in both basic and clinical. The focus of Dr. Cebulla's lab is translational research on retinal detachments and uveal melanoma.

Read More

Dawn Chandler, PhD

Our lab is interested in the regulation of pre-mRNA splicing and how disruption of this regulation can lead to pediatric diseases such as cancer. Current work in our lab elucidates alternative splicing as a novel mechanism by which cellular injury can control the activity of p53 and how changes.

Read More

Lionel Chow, MD, PhD, Affiliate

Dr. Chow's research interests have been centered on glioblastoma multiforme, a particularly devastating form of cancer in adults and children. His work has resulted in the development of a number of novel and robust laboratory models for this disease.

Read More

Susan Cole, PhD, Affiliate

The Notch signaling pathway plays key roles in human development and disease. Disregulation of Notch signaling is frequently seen in human cancers, for instance, activating Notch mutations are seen in over 50% of juvenille T-ALL cases.

Read More

Vincenzo Coppola, MD, Affiliate

Dr. Coppola’s expertise is to generate genetically modified mouse models to mimic human diseases and study gene functions in vivo. He is also interested in clarifying the role of neurotrophins (NTs) and their receptors (Trks) in vivo using specific mouse models.

Read More

Carlo Croce, MD

Dr. Croce studies the molecular changes in genes that lead to cancer. He is particularly interested in the early changes of malignancy and how they might serve as targets for new treatment and preventive agents.

Read More

Biplab Dasgupta, PhD, Affiliate

Dr. Dasagupta is interested in understanding how neural cell / stem cell metabolic and energy status is linked to cell cycle, lineage commitment, differentiation and tumorigenesis. His other interests include genetic, developmental, post-translational, tissue- and stimuli–specific regulation of.

Read More

Albert de la Chapelle, MD, PhD

Research in Dr. de la Chapelle’s laboratory focuses on the mapping, cloning, and characterization of high-and low-penetrance genes for cancer predisposition. When new genes are identified, studies are directed to determine the pathophysiological role of the proteins or RNA molecules they encode.

Read More

Nicholas Denko, MD, PhD

Dr. Denko’s research is in the study of physiology that is unique to the solid tumor. This includes gene expression changes due to oxygen deprivation (hypoxia) and nutrient stress, and the resultant changes in tumor metabolism and response to conventional therapies.

Read More

James DeWille, PhD, Affiliate

Dr. DeWille's research includes the molecular mechanisms of growth regulation.

Read More

Matthew During, MD, PhD, Affiliate

Dr. During's research includes AAV vectors in the nervous system, Canavan disease, Parkinson's disease.

Read More

Richard Fishel, PhD

Dr Fishel’s research interests includes DNA Repair defects and Genomic Instability in cancer development; biophysical chemistry of DNA repair; and single molecule imaging in vitro and in vivo. His laboratory studies the mechanisms, genetics, regulation, and consequences of DNA repair and genome.

Read More

Harold Fisk, PhD, Affiliate

Centrosomes are microtubule-organizing structures that coordinate mitotic spindle assembly and chromosome segregation. Centrosome aberrations are found in a variety of tumors, and are associated with tumorigenesis in breast cancer, prostate cancer, and leukemia.

Read More

Michael Freitas, PhD

Dr. Freitas' lab has developed extensive expertise in the field of clinical/translational proteomics, biomarker discovery/validation and bioinformatics for mass spectrometry based proteomics. Their work focuses on the determination of side chain modifications of proteins important in Chromatin.

Read More

Ramesh Ganju, PhD

The major focus of Dr. Ganju's lab is to determine the role of chemokines, especially CXCL12, and various inflammatory molecules, such as S100A7, and anti-inflammatory molecules, such as Slit2 and cannabinoids, in pathogenesis of various diseases.

Read More

Paul Goodfellow, PhD

Dr. Goodfellow’s research focuses on understanding the role that loss of DNA mismatch repair plays in tumor initiation and progression and understanding key molecular events that can be used to develop novel approaches to the prevention and treatment of endometrial cancers.

Read More

Joanna Groden, PhD

The Groden Laboratory has three primary areas of interest: the study of Bloom's syndrome, an inherited disorder that decreases chromosome stability and increases susceptibility to all types of cancer, the study of inherited disorders that increase susceptibility to colorectal cancer, especially

Read More

Erich Grotewold, PhD, Affiliate

Dr. Grotewold's research focuses on the control of gene expression and architecture of regulatory networks, using transcription factors as tools for plant metabolic engineering, sub-cellular trafficking of phytochemicals and other small molecules.

Read More

John Gunn, PhD, Affiliate

My laboratory performs research pertaining to microbial resistance to innate Immunity. Much of our research is focused on the macrophage, as well as the mucosal surface.

Read More

Metin Gurcan, PhD

Dr. Gurcan's research interests include image analysis and understanding, computer vision with applications to medicine. Over the last decade, his research contributions have concentrated on computer-aided detection and diagnosis (CAD) of cancer.

Read More

Tsonwin Hai, PhD

Maladaptation of cells to various signals plays important roles in the pathogenesis of many diseases. The current focus of my laboratory is to study the maladaptive processes in the development of breast cancer, melanoma, and diabetes.

Read More

Heather Hampel, MS, CGC

Ms. Hampel's research interests include screening all colorectal and endometrial cancer patients for Lynch syndrome, the American Founder Mutation (exon 1-6 deletion in MSH2) as a cause of Lynch syndrome, and the etiology of MSI-negative familial colorectal cancers.

Read More

Paul Herman, PhD, Affiliate

Dr. Herman's lab is interested in understanding the mechanisms Herman Lab Memberscontrolling eukaryotic cell growth and proliferation. The primary focus has been on the G0-like resting states that cells enter when conditions are not conducive to continued growth.

Read More

F. Kay Huebner, PhD

The major focus of the laboratory is to thoroughly investigate and define the biological functions of the tumor suppressor proteins, Fhit and Wwox, encoded by the chromosome fragile sites FRA3B and FRA16D, two of the most frequently inactivated tumor suppressors in a broad spectrum of human

Read More

Jaime Imitola, MD, Affiliate

Dr. Imitola directs the Neural Stem Cell Laboratory at the Department of Neurology, Ohio State University Wexner Medical Center. His research is focused on understanding the molecular mechanisms involving the cross talk between the immune system and neural stem cells genomics both in models of MS.

Read More

Krystian Jazdzewski, MD, PhD, Affiliate

The evolving awareness of microRNAs (miRs) and other non-coding RNA genes was beginning to hint that miRs might be responsible for some of the strong genetic predisposition displayed by thyroid cancer. Dr. Jazdzewski performed genetic association studies that clearly suggested such a role for.

Read More

Sissy Jhiang, PhD

Dr Jhiang current research interests are: (a) examine RET/PTC mediated signaling pathways in thyroid tumorigenesis and apply the finding to improve patients' care; (b) Investigate regulatory mechanisms of Na+/I- symporter(NIS) in thyroid cancer and breast cancer and apply the finding to develop

Read More

Lawrence Kirschner, MD, PhD

Dr. Kirschner's research is focused on endocrine tumor genetics, with specific interest in understanding how dysregulation of PKA contributes to tumorigenesis in cAMP-responsive tissues. Using a combination of in vivo mouse models and in vitro tissue culture work, his lab aims to understand how.

Read More

Katsumi Kitagawa, PhD, Affiliate

Dr. Kitagawa's research involves the role that the spindle checkpoint plays in tumor development. Mutations in genes required for kinetochore function and mitotic checkpoint surveillance possibly contribute development of cancer.

Read More

Ashish Kumar, MD, PhD, Affiliate

Dr. Kumar's research studies the biology of infant-leukemia to identify novel therapeutic approaches to treat this disease. Infants with leukemia face an exceptionally grim prognosis because the pathogenesis of the disease is different than that seen in older children.

Read More

Takeshi Kurita, PhD

Dr. Kurita's research interest lies in the molecular mechanisms of development and carcinogenesis of the reproductive organs. His lab mainly uses genetically engineered mouse models to investigate these research subjects.

Read More

Chang-hyuk Kwon, PhD, Affiliate

Dr. Kwon's laboratory is studying glioblastoma, the most aggressive and common brain malignancy with poor prognosis. By using Nf1, Trp53 and Pten conditional deletion in the brain, we have generated physiologically relevant mouse genetic models of this devastating disease.

Read More

Nam Yong Lee, PhD

Dr. Lee's research focuses on how transforming growth factor beta (TGF beta) signaling regulates vascular functions during tumor development and metastasis. Dr. Lee's lab is particularly interested in understanding the role of two endothelial-specific TGF beta receptors, endoglin and ALK1, which.

Read More

Jennifer Leight, PhD

The focus of research in the Leight lab is to utilize cutting edge biomaterials techniques to precisely vary the spatial and temporal presentation of 3D extracellular cues as well as develop new sensors to measure activity of specific members of the matrix metalloproteinase (MMP) family. Using.

Read More

Gustavo Leone, PhD

Dr. Leone’s laboratory studies the role of the Ras pathway in coordinating cell growth and cell death signals elicited by the E2F and Myc transcription programs.

Read More

Zaibo Li, MD, PhD

Dr. Li specializes in breast pathology and GYN pathology. His interests are in breast cancer biomarkers, especially HER2 related testing, along with endometrial cancer, cervical cancer and cervical cancer screening programs..

Read More

Thomas Ludwig, PhD

Dr. Ludwig's research focuses on biological function(s) of BRCA1 and BRCA2 and some of their interacting partners in normal and malignant development.

Read More

K John McLaughlin, PhD, Affiliate

Dr. McLaughlin’s laboratory has current research interests in epigenetics, stem cells and therapeutic transplant models. They use mouse transplant models in which expression of imprinted genes is abnormal in the transplanted tissue.

Read More

Nicanor Moldovan, PhD, Affiliate

a) Detection of circulating endothelial and other progenitor cells in human blood, using an original solid phase assay (called CellTrap, in development). This project is funded through an ARRA/RC2/GO stimulus grant from NIH.

Read More

Stephen Osmani, PhD, Affiliate

Dr. Osmani's research includes elucidating how the cell cycle is regulated utilizing the model filamentous fungus Aspergillus nidulans.

Read More

Jose Otero, MD, PhD

Dr. Otero's research interests include induced pluripotent stem cells, neural stem cells, cell cycle control of stem cells, and molecular diagnostics.

Read More

Ioanna Papandreou, PhD

The dysfunctional tumor vasculature and the deregulated cancer cell proliferation create areas of oxygen- and nutrient- deprivation in solid tumors. Cells within the tumor respond to these microenvironmental stresses by activating adaptive mechanisms that allow malignant progression under such.

Read More

Deborah Parris, PhD, Affiliate

Dr. Parris studies the process of HSV DNA replication. Her research covers 2 areas — coordination of lagging strand DNA synthesis and mechanisms of HSV polymerase fidelity.

Read More

Jeffrey Parvin, MD, PhD

Dr. Parvin's research involves the biological processes involved in breast cancer. His lab focuses on pathways regulated by the BRCA1 and BRCA2 tumor suppressor proteins, and these include the repair of DNA damage, control of transcription, control of cell cycle progression, and centrosome.

Read More

Yuri Pekarsky, PhD, Affiliate

Mature T-cell leukemia commonly shows chromosomal rearrangements at 14q32. 1 including translocations t(14;14)(q11;q32), t(7;14)(q35;q32) and inversions inv(14)(q11;q32).

Read More

John Phay, MD

Dr. Phay has two main research projects. The first is examining a novel AMPK activator for the treatment of thyroid cancer.

Read More

Flavia Pichiorri, PhD

Dr Pichiorri’s laboratory focuses on elucidating the mechanisms of regulation and the functional role of non-coding RNA molecules in multiple myeloma (MM) development and their role in modulating cancer microenviroment and drug resistance. She has also an active interest in providing the molecular.

Read More

Kamal Pohar, MD, Affiliate

Dr. Pohar’s research interest include: Bladder cancer, Testicular cancer, Genetic and epigenetic changes contributing to progression of bladder cancer, and Developing clinical and biologic databases in bladder cancer.

Read More

Nancy Ratner, PhD

The long term interest of the Ratner laboratory is to define the interactions between glial cells and axons during nervous system development and how those interactions go awry in disease, with the goal of providing novel therapies to patients with nervous system diseases. Neurofibromatosis type.

Read More

Grzegorz Rempala, PhD

Dr. Rempala's lab conducts high quality, original research in the areas of mathematical and applied statistics relevant to public health.

Read More

Thomas Scharschmidt, MD, Affiliate

Dr. Scharschmidt's research interests include the utility of adjuvant chemotherapy for soft tissue, sarcomas management of bone and soft tissue sarcomas, metastatic carcinoma to bone, outcome of oncologic limb salvage reconstructions, oncologic implant design, molecular biology and mechanisms of

Read More

Thomas Schmittgen, PhD

Dr. Schmittgen's research interests are Quantitative gene expression analysis and the role of small, noncoding (i. e.

Read More

Daniel Schoenberg, PhD, Affiliate

The Schoenberg lab is nationally recognized for discoveries in fundamental mechanisms of post-transcriptional gene regulation and the application of this knowledge to signal transduction, cancer and inherited diseases. The four projects currently under study look at the molecular mechanisms of.

Read More

Nilay Shah, MD, Affiliate

The primary interest of Dr. Shah’s lab is the set of aberrations that lead to embryonic cancers, i. e.

Read More

Amanda Simcox, PhD

Dr. Simcox studies EGF receptor signaling in the early wing disc. This simple system is about 30 cells in a just hatched larva and grows to about 150 cells in two days.

Read More

Jonathan Song, PhD

Dr. Song uses microscale engineering technology to reconstitute the microarchitecture of living tissue in vitro to systematically investigate how certain components of tumor microenvironment regulate angiogenesis. One of his research interests is understanding how the determinants of tumor blood.

Read More

Anne Strohecker, PhD

Dr. Strohecker is interested in understanding how autophagy, a program that regulates protein and organelle quality control, impacts tumorigenesis. Her projects focus on (i) the identification of novel autophagy regulators and their functional relevance for lung tumorigenesis, and (ii) the role.

Read More

Vish Subramaniam, PhD, Affiliate

The focus of Dr. Subramaniam’s research is on interactions between low frequency (< 1 MHz) electromagnetic waves and tissues and cells.

Read More

David Symer, MD, PhD

Dr. Symer studies mammalian retrotransposons, their epigenetic controls, and resulting functional variation. His research aims to understand some of the causes and consequences of changing epigenetic states upon the transposons, the genes and transcripts they affect, and genomic instability, with.

Read More

Amanda Toland, PhD

Dr. Toland's lab is interested in identifying naturally occurring variations in genes that affect human cancer susceptibility in order to understand how tumors grow and develop, to identify new targets for cancer therapy and prevention, and to better define a person’s risk of getting cancer. An.

Read More

Ruoning Wang, PhD

The fundamental interest of Dr. Wang's labe is to understand how eukaryotic cell integrates various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). In particular, we focus on understanding the impact of the interplay.

Read More

Robin Wharton, PhD, Affiliate

We study post-transcriptional gene regulation during development in the germ line of the model system Drosophila melanogaster. Two proteins-- Nanos and Pumilio-- collaborate to repress translation of CyclinB mRNA in the primordial germ cells, thereby blocking proliferation.

Read More

Terence Williams, MD, PhD

Dr. Wiliams' laboratory research interests center around gastrointestinal (GI) malignancies, including pancreatic cancer. they are interested in the molecular biology and genetics of DNA damage response, and those pathways which dictate tumor aggressiveness such as invasion and metastasis, and.

Read More

Christina Wu, MD

Dr. Wu’s research involves both translational and clinical studies. She is the co-principal investigator of a phase I clinical trial of trametinib, a MEK inhibitor, in combination with neoadjuvant chemoradiation in rectal cancers that have either KRAS, NRAS, or BRAF mutation, and the principal.

Read More

Jian-Qiu Wu, PhD, Affiliate

The goal of Dr. Wu's laboratory is to understand the roles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal and cancer cells. We are focusing on the molecular mechanisms of cytokinesis in the fission yeast S.

Read More

Li Wu, PhD

Dr. Wu's lab aims to better understand the mechanisms of epigenetic silencing of SAMHD1 in CTCL to develop novel therapeutic approaches. Our recent findings suggest that epigenetic silencing of SAMHD1 in malignant CD4+ T-cells contributes to uncontrolled T-cell growth in CTCL.

Read More

Fen Xia, MD, PhD

Research in the Xia laboratory focuses on elucidating the mechanisms that regulate the repair of chromosomal double-strand breaks (DSB) that arise during physiological DNA metabolism and after radiation therapy or chemotherapy. We aim to understand 1) the impact of deregulated DSB repair on.

Read More

Sung Yoon, PhD, Affiliate

The long-term goal of Dr. Yoon's lab is to understand how the balance between cell survival and death is maintained in the adult nervous system. Currently, they are focusing on the role of stress kinase, JNK signaling, under pathological conditions.

Read More

Jacob Yount, PhD

Dr. Yount's laboratory is interested in the development and implementation of tools to study protein post-translational modifications. The Yount lab is particularly interested in protein lipidations such as palmitoylation, myristoylation, and prenylation, as well as protein ubiquitination.

Read More

Weiqiang Zhao, MD, PhD

Dr. Zhao's research interest include investigating and validating biomarkers in molecular pathogenesis, diagnosis, and target intervention in cancer and leukemia. One of his projects is to study the role of isoform 6 of IKZF1 gene in leukemia or lymphoma progression which has been shown to be.

Read More

Xiaoli Zhao, PhD, Affiliate

Dr. Zhao's lab is interested in exploring the contribution of the lung epithelial cells and alveolar macrophages in these immune responses and in identifying rate-limiting components/molecules that determine the scale and direction of these immune responses. They are trying to resolve the link.

Read More

Please enter a keyword (i.e. Name, Research Interest) or choose a Research Program

OR

Please enter a keyword (i.e. Name, Cancer Type) or choose a Principle Investigator

OR

Find a Scientific Publication

Search for Clinical Trials