Meet the leaders and members of the Molecular Carcinogenesis and Chemoprevention research program at the OSUCCC – James who focus on the molecular causes and prevention of cancer.

Leaders

Steven Clinton, MD, PhD

Dr. Clinton is a physician-scientist who divides his effort between clinical care and research. He serves as director of genitourinary oncology for The James and manages the renowned Prostate Cancer Multidisciplinary Clinic.

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Members

Amit Agrawal, MD, Affiliate

Dr. Agrawal's specialty interests include head and neck oncology, facial plastic and reconstructive surgery.

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Michael Bailey, PhD

Dr. Bailey has a longstanding interest in understanding how commensal microbes impact immune system functioning, particularly during periods of endocrine activation. Studies from my laboratory, as well as others, indicate that gut microbes help to regulate the inflammatory response in both.

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Martha Belury, PhD

Dr. Belury and her lab are interested in the study of whole body energy metabolism as regulated by interactions between adipose and muscle tissues. Canonical mechanisms of energy metabolism involve insulin-dependent and –independent pathways in each of these tissues.

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Don Benson, MD, PhD

Our laboratory and clinical research programs seek to develop novel treatments for cancer that harness and enhance the immune system’s ability to detect and kill cancer cells. Natural killer cells, one type of immune cell in the body, are capable of killing cancer cells and much of the research.

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Robert Brueggemeier, PhD, Affiliate

The major research activities of Dr. Brueggemeier focus in the areas of steroid chemistry and biochemistry, hormones and cancer, medicinal chemistry, and radiochemistry. Research approaches involve the application of expertise in steroid chemistry/biochemistry to the examination of steroid.

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Richard Bruno, PhD, RD, Affiliate

The biochemical and molecular nutrition research conducted in Dr. Bruno’s laboratory aims to define the mechanisms regulating the bioavailability of dietary phytochemicals, particularly polyphenols such as quercetin and antioxidants including vitamin E, and the mechanisms by which these dietary

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Craig Burd, PhD

Dr. Burd's lab focuses on the signaling of estrogen through its cognate receptor, the estrogen receptor. Estrogen signaling plays a central role in breast cancer development and progression and deregulated activity influences therapeutic relapse.

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Bruce Casto, Dr Sc (Affiliate), Affiliate

Dr. Casto's research interests involve chemopreventive agents in animal and in vitro models of oral, lung, and colon cancers, including studies of whole foods as cancer preventives.

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Ching-Shih Chen, PhD

Dr. Chen's research focuses on exploring signaling pathways that govern cancer cell survival as targets for drug discovery and design. He employs a multidisciplinary approach to identify new molecular targets by combining a wide range of expertise encompassing synthetic medicinal chemistry.

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Tong Chen, MD, PhD

Dr. Chen's interests include research in investigations of the mechanism(s) through which natural food products (i. e.

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Christopher Coss, PhD

Dr. Coss' research focuses on endocrine disease mechanisms and developing novel therapies for advanced prostate cancer. He also has an interest in chemoprevention of prostate and hepatocellular carcinomas using novel hormonal approaches.

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Robert Curley, Jr., PhD

Dr. Curley has a longstanding interest in the chemistry and biochemistry of the fat-soluble vitamins, particularly vitamin A, and their bioactive metabolites with a particular emphasis on their potential as cancer preventive and treatment agents.

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Steven D'Ambrosio, PhD, Affiliate

Our research is in the area of cancer prevention using natural and synthetic products. Our aims are to identify: (1) individual and combined products which prevent the growth of premalignant and cancer cell types; and (2) determine the cellular targets mechanisms by which these compounds act.

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Robert DiSilvestro, PhD, Affiliate

Phytochemicals are food components from plants that are not strictly required for normal function, but can have health promoting properties. These health promoting properties can include reducing cancer risk.

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Andrea Doseff, PhD, Affiliate

Dr. Doseff's research explores various molecular and biochemical mechanisms that regulate cell death. Furthermore, her lab also concentrates on different signal transduction pathways that control apoptosis.

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Mark Failla, PhD

Dr. Failla and his research team are interested in the digestive stability, intestinal cell uptake, absorption, and functions of health-promoting compounds in foods. He primarily focuses on two families of compounds in plant foods, carotenoids and soy isoflavonoids.

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William Farrar, MD

Dr. Farrar's research interests include the study bioactive food components with cancer-preventative properties and to examine key epigenetic processes in order to begin to establish linkages between epigenetics, methylation patterns, and tumor incidences/behaviors.

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Avner Friedman, PhD

Dr. Friedman's research includes partial differential equations, mathematical biology, stochastic differential equations and control theory, particularly mathematical models of carcinogenesis and hormone therapy in prostate cancer.

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Gayle Gordillo, MD

Dr. Gordillo's team works on multiple different projects studying mechanisms regulating angiogenesis in both wound healing and endothelial cell tumor biology.

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Earl Harrison, PhD

Dr. Harrison’s laboratory studies the basic mechanisms involved in the intestinal absorption, transport, and metabolism of dietary vitamin A and carotenoids using cell culture, animal models, and investigations in human subjects. He is particularly interested in defining the proteins involved in.

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A. Douglas Kinghorn, PhD, DSc

Dr. Kinghorn has worked for about 30 years on the discovery of new anticancer agents from mainly tropical plants. For over a decade while at the University of Illinois at Chicago, Dr. Kinghorn served as Principal Investigator of a National Cooperative Drug Discovery Groups (NCDDG) project entitled.

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Thomas Knobloch, MS, PhD, Affiliate

Dr. Knobloch's interests include the mechanisms of molecular carcinogenesis and their interaction with food-based cancer risk reduction strategies following a "Bench to Bedside," "Crop to Clinic," and "Farm to Pharma" philosophy. Dr. Knobloch's work currently emphasizes the role of black raspberry.

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Purnima Kumar, PhD, DDS

Oral bacterial profiles associated with periodontal health and disease, including a) characterization of subgingival microbial profiles of periodontally healthy smokers and smokers with periodontitis, and b) the role of host genetics on oral bacterial colonization.

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Gregory Lesinski, PhD

Dr. Lesinski’s research is focused on gaining a greater understanding of the interactions between the host immune system and tumor cells. The ultimate goal is to use this knowledge to develop novel therapeutic or chemo-preventative approaches to help patients with cancer, and improve upon.

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Pui-Kai Li, PhD, Affiliate

The research area of Dr. Li focuses in the design, synthesis and biochemical testing of steroidal and non-steroidal steroid sulfatase inhibitors as potential agents for the treatment of hormone-dependent cancers.

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Young Lin, DVM, PhD, Affiliate

Dr. Lin's research projects are relevant to the human nutrition for chemoprevention and tumorigenesis of bio-active food component in human diets

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Susan Mallery, DDS, PhD

Dr. Mallery's research interests include Oral pathology, Oral cancer initiation; AIDS-related oral cancer; and chemoprevention

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Clay Marsh, MD, Affiliate

Focusing on the mechanisms underlying human health and disease, we have projects ranging from biomarker discovery using microRNA molecules to define genetic pathways and proteins important in tissue environments including breast cancer, lung cancer, lung fibrosis, and melanoma; cell biology

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Anjali Mishra, PhD

Dr. Mishra's research has shown stage-related ‘interleukin-15 (IL-15)’ mRNA and protein over-expression in lesional skin and circulating tumor cells of CTCL patients. Using IL-15 transgenic (tg) mice, Dr. Mishra's lab has characterized an animal model of spontaneous epidermotropic T-cell lymphoma.

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Amir Mortazavi, MD, Affiliate

Dr. Mortazavi's research interests include epigenetic modifications and experimental therapeutics for the prevention and treatment of genitourinary cancers.

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Peter Muscarella, MD, Affiliate

Pancreatic cancer is currently the fourth most common cancer causing death in the United States. The overall prognosis remains poor despite advances in diagnostic tests, surgical technique, multimodality treatment, and postoperative care.

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Tatiana Oberyszyn, PhD

Studies in the Oberyszyn skin carcinogenesis laboratory are designed to increase our understanding of the function of biological mediators including prostaglandins, cytokines and reactive oxygen intermediates during Ultraviolet Light induced Squamous Cell Carcinoma development. Current studies are.

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Zui Pan, PhD

The long-term goal of Dr. Pan’s laboratory is to search for effective prognostic biomarkers and potential therapeutic means for treatment of esophageal cancers by targeting Ca2+ signaling pathway. Of particular interests are Orai1, an important Ca2+ channel involved in cancer cell proliferation.

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Dehua Pei, PhD

Dr. Pei's interest is in a variety of problems at the interface of chemistry and biology. A major area is to determine the molecular basis of biological processes by chemical methods.

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Michael Pereira, PhD, Affiliate

Current research involves identification of new chemopreventive agents, and determination of their efficacy and mechanism of action. The identification and determination of the efficacy of new chemopreventive agents has focused on drugs including NSAIDs, retinoids, and HDAC inhibitors.

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Harinantenaina Rakotondraibe, PhD, Affiliate

New natural product sources (new and unidentified fungal and bacterial microorganisms, plant endophytes, new endemic and medicinal plant species, etc. ) contain many undiscovered potential bioactive metabolites which can combat the world’s deadly diseases including cancer, malaria, viral.

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Kenneth Riedl, PhD

Dr. Riedl is a research scientist and associate director of the Nutrient & Phytochemical Analytic Shared Resource (NPASR) of the OSU-CCC. He provides method development and analysis expertise for nutrients, phytochemicals, their metabolites, and metabolomics experiments primarily for cancer.

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Thomas Rosol, DVM, PhD

Dr. Rosol's Laboratory is NCI and NCRR-funded to develop mouse models of human cancer with emphasis on bone metastasis, bone resorption and formation, and cancer-associated hypercalcemia. The molecular regulation of parathyroid hormone-related protein (PTHrP) is studied in vitro and in vivo using.

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Steven Schwartz, PhD

Dr. Schwartz' research interests include: • Metabolic profiling, targeted and untargeted metabolomics related to food and nutrition for health; Bioavailability, metabolism, and physiological significance of carotenoids, isothiocyanates, isoflavones and other phytochemicals; Phytochemicals and

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Chandan Sen, PhD

Dr. Sen’s program is interested in tissue injury and repair and works across three organ systems- skin, brain and heart. His group is interested in miRNA biology, redox signaling and tissue oxygenation.

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Colleen Spees, PhD, MEd, RD, LD

Dr. Spees is an Assistant Professor in the Division of Medical Dietetics and Health Sciences in the School of Health and Rehabilitation Sciences College of Medicine with a focus on nutrition and cancer. Her laboratory research focuses on evaluating biomarkers of nutritional and dietary.

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Yael Vodovotz, PhD

Dr. Vodovotz' research is focused on the physico-chemical changes of functional foods during formulation, processing and storage as they impact the delivery of bioactives. Her lab utilizes molecular, structural and macroscopic analysis to fully characterize food material behavior in different.

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Qianben Wang, PhD

Dr. Wang's laboratory is interested in understanding the role of androgen receptor (AR) in the development and progression of prostate cancer. AR is a ligand-dependent transcription factor belonging to the nuclear hormone receptor (NR) superfamily.

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Qi-En Wang, PhD

The focus of Dr. Wang's research is on the regulation of nucleotide excision repair (NER), one of the DNA repair pathways, and the connection of DNA repair to cancer therapy. Dr. Wang's research strives to explore the mechanism of NER, and finally find means to prevent cancer initiation via.

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Altaf Wani, PhD

Dr. Wani's research interests include Molecular carcinogenesis-analysis, fine mapping and cellular processing of specific genotoxic base lesions, mutagenesis, apoptosis and other DNA damage responses.

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Christopher Weghorst, PhD

Dr. Weghorst and his research team are recognized nationally as a leader in the areas molecular and comparative carcinogenesis, focusing on the biological mechanisms, genetic susceptibility and chemoprevention of head and neck and cervical cancer development. His research program has three primary.

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Mark Wewers, MD, Affiliate

Dr. Wewer’s research focuses on host defense against pathogens, particularly relevant to the lung and critical to survival His lab is interested in understanding the role of proteins that regulate the activation of the intracellular enzyme, caspase-1. This work is relevant to understanding how.

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Traci Wilgus, PhD

Dr. Wilgus studies the involvement of the pro-angiogenic growth factor vascular endothelial growth factor (VEGF) in skin carcinogenesis. VEGF is known to contribute to skin carcinogenesis by enhancing angiogenesis.

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Lisa Yee, MD

Dr. Yee’s interests are in gene-nutrient interactions that affect the development and progression of breast cancer. In the laboratory she is investigating the mechanism(s) by which dietary fat content affects HER-2/neu signal transduction in mammary carcinogenesis.

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Jianhua Yu, PhD

Dr. Yu's research interests include Immuno-cellular therapy, blood and marrow transplantation, NK cell biology, gene regulation and cell signaling in immune response and malignant transformation

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Ouliana Ziouzenkova, PhD

Dr. Ziouzenkova's laboratory studies how nutrients regulate genes and can prevent metabolic diseases, such as obesity and type 2 diabetes. They are creating anti-obesity therapies based on cell engineering and nanotechnology that could have an impact on global obesity epidemics.

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Xianghong Zou, PhD, Affiliate

Dr. Zou's research goals include the development of therapeutic strategies to target the cell cycle machinery especially for aggressive and metastasis cancer, and dissect their molecular mechanism by applying various technique in molecular, cellular & developmental biology and animal models.

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