Shared Resources and Cores

The OSUCCC – James has 20 Shared Resources and Cores that provide specialized services to cancer researchers. They offer cost-effective, state-of-the-art technology and instrumentation; expert guidance and training; and clinical, administrative and technical support.

Funding for the Shared Resources comes from the OSUCCC, the OSUCCC Cancer Center Support Grant from the National Cancer Institute, partnerships with The Ohio State University colleges and departments, and established chargeback systems.

Analytical Cytometry

Analytical Cytometry is a quantitative analytical method that separates cells based on specific characteristics. It can also measure physical and chemical properties of cells and particles. ACSR provides state-of-the-art flow cytometry analysis and sorting of cell populations using selected cellular markers.

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Behavioral Measurement

The Behavioral Measurement Shared Resource (BMSR) assists investigators who wish to incorporate behavioral research into the broader research goals of the OSUCCC – James. The BMSR provides expertise and training to support the needs of prevention, cancer control, and clinical researchers in their pursuit of behavioral research investigation and methods.

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Biomedical Informatics

The Biomedical Informatics Shared Resource (BISR) analyzes high-throughput, high dimensional biological data and other biomedical data and information using state-of-the-art informatics tools and high-quality informatics analysis for OSUCCC – James investigators. The BISR has two service arms: Computational Biology Services and Data Sharing Infrastructure.

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Biospecimen Services

The broad mission of the OSUCCC Biospecimen Services Shared Resource (BSSR) is to support cutting edge translational research to advance the prevention, diagnosis and treatment of cancer.

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Biostatistics

The Biostatistics Shared Resource (BSR) provides expertise in the biostatistical design and analysis of clinical, basic and population-based research. BSR services enable OSUCCC – James researchers to collaborate on all aspects of experimental design; grant proposal development; data management and statistical analysis of clinical, epidemiological, public-health and laboratory research data; and manuscript preparation.

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Clinical Treatment Unit and Clinical Trials Processing Laboratory

Discover the resources available to OSUCCC – James cancer researchers through the Clinical Treatment Unit and Clinical Trials Processing Laboratory.

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Clinical Trials Office

The Clinical Trials Office (CTO) facilitates development and implementation of all OSUCCC – James clinical trials, including regulatory processing, subject recruitment, data collection, and protocol-management services. By centralizing all of these services, this shared resource helps investigators conduct methodologically sound, expedient and cost-effective clinical trials.

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Comparative Pathology and Mouse Phenotyping

The Comparative Pathology and Mouse Phenotyping Shared Resource (CPMPSR) provides expert, affordable, experimental pathology support to OSUCCC – James researchers who use animal models to study human disease. CPMPSR comparative pathologists are experts in the normal anatomy and physiology, and in background age- and strain-/breed-related lesions, infectious pathogens and husbandry practices of various animal model species.

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Genetically Engineered Mouse Modeling

Modeling human disease in mouse provides a powerful tool for elucidating mechanisms and interrogating experimental therapeutics. The Genetically Engineered Mouse Modeling Core (GEMMC) is available to investigators who work or intend to work with mouse models of human disease.

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Genomics

The Genomics Shared Resource (GSR) provides both Nucleic Acid services and Microarray services. It offers instrumentation and expertise for DNA and RNA analysis using sequencing, genotyping, real-time PCR, Affymetrix GeneChips, nCounter Analysis, next-generation sequencing, DNA synthesis support and genome-wide analysis using the Illumina NGS platform and Affymetrix and customizable gene chips.

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Leukemia Tissue Bank

The Leukemia Tissue Bank Shared Resource helps scientists translate basic research to the clinical setting by providing central collection, processing and storage of tissue samples from patients with leukemia, myeloma or lymphoma enrolled on OSUCCC – James protocols.

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Medicinal Chemistry

The Medicinal Chemistry Shared Resource (MCSR) provides medicinal chemistry support to investigators at the OSUCCC – James and to other academic and commercial institutions. It integrates the expertise of multiple disciplines, including synthetic and process chemistry, instrumental analysis and molecular pharmacology.

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Microscopy

The Microscopy Shared Resource (MSR) gives researchers access to state-of-the-art microscopes and to services ranging from standard light and electron microscopy to leading-edge, live-animal, multiphoton microscopy. MSR experts support high-level cancer research with the latest microscopy techniques.

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Nutrient and Phytochemical Analytics

The Nutrient and Phytochemical Analytics Shared Resource (NPASR) provides investigators with expert bioanalytical method development and quantitative analysis. This resource supports development of methods and techniques to quantitatively determine nutrients and phytochemicals in foods. It also identifies these compounds and their metabolites in biological samples from human clinical trials and animal model investigations.

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Pharmacoanalytical

The Pharmacoanalytic Shared Resource (PhASR) supports pre-clinical and clinical drug development at Ohio State by providing high quality and cost-effective bioanalytical method development, quantitative sample analysis, and pharmacokinetic/pharmacodynamic experimental design, data analysis and modeling.

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Proteomics

The Proteomics Shared Resource (PSR) provides OSUCCC investigators access to advanced mass spectrometry instrumentation and analysis for protein identification, characterization, and quantification. PSR provides cancer researchers with technical expertise and state-of-the-art instrumentation needed to identify proteins, protein modifications, protein interactions and protein biomarkers as well as protein quantitation studies in cancer samples.

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Small Animal Imaging Core

The Small Animal Imaging Core (SAIC) is a state-of-the-art, small-animal imaging facility available to OSUCCC – James investigators and other academic and commercial institutions. The SAIC houses high-resolution imaging equipment and offers assistance from professionals who are experts in operating each imaging modality, small animal handling, and analytical software support for quantitative image analysis.

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Solid Tumor Translational Science

​The Solid Tumor Translational Science Shared Resource (STTSSR) team works closely with clinical and translational scientists to develop a customizable portfolio of biomarker assays in order to provide innovative, correlative science studies associated with early-phase solid tumor oncology clinical trials.

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Target Validation

The Target Validation Shared Resource (TVSR) assists investigators in generating reliable proof-of-concept preclinical animal model data for grant applications, publications and IND applications for the FDA. The goal of TVSR is to assist investigators in generating reliable “proof-of-concept” preclinical animal (mouse) model data for grant applications, publications and filing of IND applications to FDA.

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Veterinary Clinical Research Support

The Veterinary Clinical Research Support Shared Resource (VCRSSR) designs and conducts clinical trials in companion animals with spontaneous diseases to evaluate novel diagnostics and therapeutics and collects biospecimens, such as tissue biopsies, serum, plasma and urine, in support of comparative cancer research.

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