Analytical Cytometry


Analytical Cytometry is a quantitative analytical method that separates cells based on specific characteristics. It can also measure physical and chemical properties of cells and particles.

The Analytical Cytometry Shared Resource (ACSR) provides state-of-the-art flow cytometry analysis and sorting of cell populations using selected cellular markers. Flow cytometry is a critical technology for cancer research, and the ACSR is used extensively by all scientific programs in the OSUCCC – James and by the broader Ohio State research community.

Researchers can learn more about the use and application of flow cytometry in several ways, including scientific seminars, marketing at cancer-specific meetings, instrumentation overviews and application workshops. Additionally, the Mid-Ohio Cytometry Associates “users’ group” meets regularly to discuss relevant cytometry issues and to generate educational opportunities.

ACSR’s Goals

  • Provide state-of-the-art flow cytometry analysis and sorting on a fee-for-service basis. Additionally, assist investigators with experimental design and assay development.

  • Provide individual training and then 24-hour access to flow cytometry instrumentation for researchers who wish to conduct their own analysis.

  • Develop and provide educational and training opportunities for new and experienced resource users.

  • Provide forums to introduce new instrumentation, technologies and reagents to OSUCCC – James investigators.

  • Obtain and provide state-of-the-art equipment to support high-quality cancer research for OSUCCC – James members.

  • Introduce new, or pre-commercial, emerging technology to support high-quality cancer research for OSUCCC – James members.

The ACSR supports the training of postdoctoral scientists and graduate students in OSUCCC – James laboratories and helps members obtain extramural funding by supporting high-quality cytometry experimental design.

The ACSR is supported by extensive institutional commitments.

Expertise

The ACSR provides substantial technical expertise and training for state-of-the-art cytometry instruments in order to address fundamental cancer research questions. Through a variety of educational outreach activities, OSUCCC members are introduced to new instrumentation, technology and methodologies being developed at Ohio State and other key allied organizations.

Director: Jeffery Chalmers, PhD        
Manager: Bryan McElwain, BS, MS, MBA
Lab Services Coordinator: Katrina Moore, BS   

Jeffrey Chalmers, PhD, Director of the Cytometry Shared Resource, is also a professor in Ohio State’s Department of Chemical and Biomolecular Engineering and an adjunct staff member for the Cleveland Clinic’s Department of Biomedical Engineering, Research Institute. 

He earned his BA in Chemical Engineering from Westmont College; his BS in Chemical Engineering from the University of California, Berkeley; and his PhD in the same field of study from Cornell University. 

In addition to being the director of Analytical Cytometry Shared Resource, Dr. Chalmers serves on the Biotechnology and Bioengineering Editorial Board, and associate editor of PLoSONE, and served a term as an NIH ISD study section member. An elected Fellow of the American Association for the Advancement of Science and an elected Fellow of the American Institute of Biomedical and Biological Engineers, Dr. Chalmers has received numerous professional awards and distinctions, including the 2014 Cell Culture Engineering Award. He has also published more than 120 peer-reviewed papers, 11 book chapters and one book.

Bryan McElwain, MS, MBA, is the ACSR Manager. He received his Bachelor of Science degree from St. Bonaventure University and his MS from the State University of New York at Buffalo. He studied cytometry during his master’s thesis on immunology at the Roswell Park Cancer Institute. 

Bryan has been managing the BRT core facility since 2004, gaining professional experience in designing, consulting and training facility on cytometry applications, experimental design and instrument training. He has expertise on the BD FACS Aria, BD FACS Calibur, BD FACS LSRII, and the BD FACS Vantage.

Katrina Moore, BS, is the Lab Services Coordinator. She received her Bachelor's degree in Microbiology and Molecular Genetics from Michigan State University in 2007. Katrina has worked for the Analytical Shared Resource since 2008 and has extensive experience in experimental design, cytometry applications and training. She has expertise on the BD FACS Arias, BD FACS Calibur, and BD FACS LSR II.

Contact Us

BRT Facility
1055/1063 Biomedical Research Tower
460 West 12th Ave.
Columbus, OH 43210
Phone: 614-292-FLOW (3569)

Bryan McElwain
Laboratory Manager
Bryan.McElwain@osumc.edu

Katrina Miller
Laboratory Coordinator
Katrina.Miller@osumc.edu

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