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Services

The goal of the BBR is to facilitate biomedical research using tissues at The Ohio State University. 

The following services are currently offered to support this goal: 

Formalin-fixed paraffin-embedded tissue: Formalin Fixed Paraffin Embedded. Tissue is fixed in formalin and then dehydrated. Tissue is then embedded in paraffin. Block can be cut to make slides. 

Frozen: Tissue comes to the lab from the OR sterile. The lab uses methods “as clean as possible” to procure the tissue. The tissue is frozen in liquid nitrogen and then stored at -80 until transferred to the BBR lab at Polaris. The sample is frozen long-term in a liquid nitrogen freezer. 

Frozen OCT (Optimal Cutting Temperature– compound):  Fresh tissue is placed into molds containing OCT compound (liquid) which is frozen at -80 to form hardened blocks; the preparation of the sample is much more rapid than with traditional histology technique (around 10 minutes vs. 16 hours). OCT can be cut to make slides without further embedding. The final slides can be used for in situ hybridization, etc. This is a method for saving tissue for future usage.

Frozen RNA Later:  RNAlater® solution is an aqueous, nontoxic tissue storage reagent that rapidly permeates tissues to stabilize and protect cellular RNA. RNAlater® solution eliminates the need to immediately process tissue samples or to freeze samples in liquid nitrogen for later processing. Tissue pieces can be harvested and submerged in RNAlater® solution for storage without jeopardizing the quality or quantity of RNA obtained after subsequent RNA isolation. Banked frozen serum/plasma specimen: Investigator is provided banked frozen serum or plasma specimen. 

Unstained frozen section: Investigator is provided an unstained slide of sectioned frozen tissue specimen. See pricing list for charges. 

H&E-stained paraffin section: Investigator is provided an H&E-stained slide of sectioned paraffin tissue specimen. See pricing list for charges. 

Unstained paraffin section: Investigator is provided an unstained slide of sectioned paraffin tissue specimen. See pricing list for charges. 

Data: Samples are obtained through the BBR Bank, while any data is received through the Information Warehouse. The Information Warehouse will be able to link the specimen sample via the BSN listed on the sample to Identifiable or de-identifiable data depending upon your IRB Approval. 

Quality Control of Slides: A pathologist performs review of H&E-stained slide(s) from a surgical case. No extra charge if provided with tissue specimen.

Request Process

The BBR operates under the following methods for sample distribution:

  • IRB Approval – IRB Approval letter required from the IRB
  • IRB Exemption – IRB Exemption letter required from the IRB
  • The Office of Responsible Research Practices (ORRP) Non-human subjects determination—The BBR is not currently distributing under this function—ORRP non-human subjects determination letter required. This will allow investigators to receive de-identified data from the Information Warehouse (IW) Honest Broker. An Honest Broker data request is a one-time data request.

Service Requests

BBR Application and Investigator Agreement on located on eRAMP.

Fees

Banked frozen tissue specimen
$40.00 specimen

Banked frozen tissue specimen w/consent
$30.00 specimen

Banked frozen tissue specimen w/consent & collect
$20.00 specimen

Banked paraffin tissue specimen
$30.00 specimen

Banked paraffin tissue specimen w/consent
$20.00 specimen

Banked paraffin tissue specimen w/consent & collect
$15.00 specimen

Banked RNA Later (DNA specimen)
$40.00 specimen

Banked RNA Later (DNA specimen) w/consent
$30.00 specimen

Banked RNA Later (DNA specimen) w/consent & collect
$20.00 specimen

Banked frozen tissue preserved in OCT
$40.00 specimen

Banked frozen tissue preserved in OCT w/consent
$30.00 specimen

Banked frozen tissue preserved in OCT w/consent & collect
$20.00 specimen

Banked frozen serum/plasma specimen
$25.00 specimen

Banked frozen serum/plasma specimen w/consent
$20.00 specimen

Banked frozen serum/plasma specimen w/consent & collect
$15.00 specimen

Banked frozen WBC specimen
$25.00 specimen

Banked frozen WBC specimen w/consent
$20.00 specimen

Banked frozen WBC specimen w/consent & collect
$15.00 specimen

Banked frozen other fluids
$25.00 specimen

Banked frozen other fluids w/consent
$20.00 specimen

Banked frozen other fluids w/consent & collect
$15.00 specimen

H&E stained frozen sect. slide from OCT spec.
$20.00 per slide

H&E stained frozen sect. slide from OCT spec. w/consent
$15.00 per slide

H&E stained frozen sect. slide from OCT spec. w/consent & collect
$10.00 per slide

Unstained frozen sect slide from OCT specimen
$16.00 per slide

Unstained frozen sect slide from OCT specimen w/consent
$12.00 per slide

Unstained frozen sect slide from OCT specimen w/consent & collect
$8.00 per slide

Addn'l unstained frozen sect. slide from OCT specimen
$8.00 per slide

Addn'l unstained frozen sect. slide from OCT specimen w/consent
$6.00 per slide

Addn'l unstained frozen sect. slide from OCT specimen w/consent & collect
$4.00 per slide

H&E stained slide from paraffin section
$16.00 per slide

H&E stained slide from paraffin section w/consent
$12.00 per slide

H&E stained slide from paraffin section w/consent & collect
$8.00 per slide

Unstained slide from paraffin section
$14.00 per slide

Unstained slide from paraffin section w/consent
$10.00 per slide

Unstained slide from paraffin section w/consent & collect
$6.00 per slide

Addn'l unstained slide from paraffin section
$8.00 per slide

Addn'l unstained slide from paraffin section w/consent
$6.00 per slide

Addn'l unstained slide from paraffin section w/consent & collect
$4.00 per slide

First sample
$25.00 per case

Second sample
$12.00 per case

Additional processing of tissue from original segment
$12.00 per case

Formalin-fixed paraffin-embedded tissue specimen
$20.00 specimen

Formalin-fixed paraffin-embedded tissue specimen w/consent
$10.00 specimen

Formalin-fixed paraffin-embedded tissue specimen w/consent & collect
$8.00 specimen

H&E stained slide from frozen section
$20.00 per slide

H&E stained slide from frozen section w/consent
$15.00 per slide

H&E stained slide from frozen section w/consent & collect
$10.00 per slide

Unstained slide from frozen section
$16.00 per slide

Unstained slide from frozen section w/ consent
$12.00 per slide

Unstained slide from frozen section w/consent & collect
$8.00 per slide

Scroll
$2.50 specimen

Micron sections
$7.00 specim

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