The Comparative Pathology and Mouse Phenotype Shared Resource (CPMPSR) provides expert, affordable, experimental pathology support to OSUCCC – James researchers who use animal models to study human disease.

CPMPSR comparative pathologists are experts in the normal anatomy and physiology, and in background age- and strain-/breed-related lesions, infectious pathogens and husbandry practices of various animal model species. Lesion recognition and interpretation within individual investigations provides a critical component to research that incorporates animal models.

Expertise

The CPMPSR is located in Ohio State’s College of Veterinary Medicine and has access to veterinary pathology expertise from 13 board certified veterinary pathologists in the Department of Veterinary Biosciences. Additional expertise is available to CPMPSR clients by veterinary radiologists, ophthalmologists and cardiologists in the College of Veterinary Medicine.

  • CPMPSR Director: Krista M.D. La Perle, DVM, PhD, Dipl. ACVP

  • CPMPSR Associate Director: Brad Bolon, DVM, MS, PhD, Dipl. ACVP and ABT

  • Medical Laboratory Technologist: Jody Sneddon, MT (ASCP) SH

  • Research Assistant: Julie Rectenwald, AHT, MLT

  • Lab Demonstrator (virtual microscopy): Jenny Bolon, RVT

  • Histology/Immunohistochemistry Laboratory Manager: Alan Flechtner, BS, HTL (ASCP)

  • Histotechnician: Bill Kimble

  • Histotechnician: Anne Saulsbery, AA, HT (ASCP)

  • Immunohistotechnician: Florinda Jaynes, HT (ASCP)

Krista M.D. La Perle, DVM, PhD, Dipl. ACVP, is the CPMPSR director and an associate professor at The Ohio State University.

As CPMPSR director, Dr. La Perle oversees all CPMPSR operations and projects, including pre-submission consultations, macroscopic lesion interpretation, histologic tissue evaluation, clinical pathology data interpretation and final report preparation. She also meets with investigative staff to discuss findings, demonstrate pertinent lesions, recommend ancillary tests and plan subsequent studies.

Dr. La Perle is an expert in veterinary comparative pathology: she completed her postdoctoral training in veterinary anatomic pathology at Ohio State and is board certified by the American College of Veterinary Pathologists. She obtained her PhD in Experimental and Molecular Pathology from Ohio State, where her National Institutes of Health-funded research focused on animal models of thyroid cancer and developing gene therapy strategies of sodium/iodide symporter-mediated radionuclide imaging and therapy for cancer.

Prior to her position as the CPMPSR director, Dr. La Perle established the Genetically Engineered Mouse Phenotyping Service and was director of the Laboratory of Comparative Pathology for Memorial Sloan-Kettering Cancer Center, Weill Medical College of Cornell University and Rockefeller University in New York City.

Brad Bolon, DVM, MS, PhD, Dipl. ACVP and ABT, is the CPMPSR associate director and an associate professor at The Ohio State University.

Dr. Bolon shares responsibility for all projects with Dr. Krista La Perle, including pre-submission consultations, macroscopic lesion interpretation, histologic tissue evaluation, clinical pathology data interpretation and final report preparation. He also meets with investigative staff to discuss findings, demonstrate pertinent lesions, recommend ancillary tests and plan subsequent studies.

Prior to his recruitment to Ohio State, Dr. Bolon founded GEMpath, Inc., a company that supported basic bio/pharmaceutical research, emphasizing morphologic analysis of genetically engineered (especially developing) mice, target validation, and efficacy and safety studies (rats, rabbits, dogs, primates) for proteins and small molecules.

Dr. Bolon has led teams that morphologically characterized genetically engineered animal models for human cardiovascular, endocrine, metabolic and neural diseases using in situ molecular assays (e.g., nucleic acid hybridization), and has been a leader in designing and managing core services for microscopy, photomicrography, and digital imaging in his roles at Pathology Associates International, Wyeth-Ayerst Research and Amgen. He has an extensive background in veterinary pathology with specific training and expertise in comparative pathology, developmental pathology, neuropathology, and toxicologic pathology, including training to assess anatomic, behavioral, and neurochemical disruption in brains of prenatal and neonatal mice exposed to either fungal toxins or industrial solvents.

Jody Sneddon, MT (ASCP) SH, is a medical laboratory technologist for the CPMPSR.

With over 24 years’ experience working in clinical pathology laboratories at Nationwide Children’s Hospital, Sneddon processes all clinical pathology specimens for in-house analysis, submits specimens to reference laboratories, reports clinical pathology results to investigators and pathologists and archives results and blood smears/cytology slides.

Sneddon received her BS in Medical Technology from Ohio State and is certified as a Medical Technologist and a Specialist in Hematology from the American Society for Clinical Pathology.

Julie Rectenwald, AHT, MLT, research assistant, is an expert in coordinating histopathology for good laboratory practice (GLP) animal studies and has more than 15 years of experience in the field.

Rectenwald processes samples, performs gross dissections, collects blood samples, weighs animals and tissues, identifies gross lesions, and harvests and trims tissues for histology. Additionally, she takes digital gross photographs and performs radiography, offers investigators instruction on tissue collection, fixation and trimming, and assists investigators with organizing and coordinatinganimal studies.

Rectenwald received Associate of Applied Sciences degrees in Animal Health Technology and Medical Laboratory Technology from Columbus Technical Institute and Columbus State Community College, Columbus, Ohio, respectively.

Jenny Bolon, RVT, is a veterinary technologist and virtual microscopy lab demonstrator. She performs digital slide scanning with the Aperio ScanScope XT and helps Drs. La Perle and Bolon fine-tune algorithms for quantitative image analysis using the Aperio Toolbox Software. Prior to joining the CPMPSR and the Department of Veterinary Biosciences in December 2013, Bolony supported radiographic, fluoroscopic and MRI imaging of Ohio State Veterinary Medical Center patients for more than 23 years.

Alan Flechtner, BS, HTL (ASCP), manages the histology/immunohistochemistry laboratory. A histotechnologist certified by the American Society of Clinical Pathologists (ASCP), Flechtner has more than 17 years of experience in all aspects of histology/immunohistochemistry and is responsible for technical and administrative oversight of the CPMPSR histology/immunohistochemistry lab.

Flechtner received his BS in Biology from Heidelberg College, Tiffin, Ohio.

Anne Saulsbery, AA, HT (ASCP), histotechnician, has more than 12 years of expertise in embedding, sectioning and performing routine and special histochemical stains.

Saulsbery received her Associate of Applied Sciences degree from Columbus State Community College, Columbus, Ohio, and is certified by the American Society of Clinical Pathologists (ASCP).

Bill Kimble, histology technician, offers investigators more than 12 years of expertise in embedding, sectioning and performing routine and special histochemical stains.

Kimble has a certificate in Histology from Columbus State Community College, Columbus, Ohio.

Florinda Jaynes, HT (ASCP), immunohistotechnician, offers investigators more than 25 years of experience in histology and immunohistochemistry.

She is responsible for all aspects of the CPMPSR’s immunohistochemistry, including optimizing antigen retrieval techniques, novel antibodies and numerous detection methods.

Jaynes is certified by the American Society of Clinical Pathologists (ASCP).

Cross-Institutional Work

The CPMPSR is used primarily by OSUCCC – James researchers and other investigators at Ohio State and affiliated institutions.

Contact Us

Comparative Pathology & Mouse Phenotyping Shared Resource Main Laboratory

Ohio State’s College of Veterinary Medicine
467/471 Veterinary Medicine Academic Building
1900 Coffey Rd.
Columbus, Ohio 43210

Phone: 614-247-8122
Fax: 614-292-6473
Email: CPMPSR@cvm.osu.edu 

Availability: Monday – Friday
Hours: 8 a.m. – 5 p.m.

Histology/Immunohistochemistry Laboratory

Ohio State’s College of Veterinary Medicine
302 Goss Laboratory
1925 Coffey Rd.
Columbus, Ohio 43210

Phone: 614-292-3327
Fax: 614-292-6473
Email: CPMPSR@cvm.osu.edu

Availability: Monday – Friday
Hours: 8 a.m. – 5 p.m.

Digital Microscopy and Image Analysis Suite
Ohio State’s College of Veterinary Medicine
310 Goss Laboratory
1925 Coffey Rd.
Columbus, Ohio 43210

Phone: 614-247-4795
Fax: 614-292-6473
Email: CPMPSR@cvm.osu.edu

Availability: Monday – Friday
Hours: 8 a.m. – 5 p.m.

Six-Headed Microscope Laboratory
933 Biomedical Research Tower
460 W. 12th Ave.
Columbus, Ohio 43210

Phone: 614-247-6879
Fax: 614-292-6473
Email: CPMPSR@cvm.osu.edu

Availability: Scheduling upon request
Hours: Scheduling upon request

Please enter a keyword (i.e. Name, Research Interest) or choose a Research Program

OR

Please enter a keyword (i.e. Name, Cancer Type) or choose a Principle Investigator

OR

Find a Scientific Publication