Power to Change Lives

The following video contains a story of a patient whose life has been changed by research and treatment at The Ohio State University Cancer Center. You will hear a real story that demonstrates why The Power to Change Lives exists in all of us.

Carl Stewart

In 1998, Carl Stewart was told he had only a short time to live after doctors found a large lymphoma tumor in his brain. The tumor likely stemmed from a kidney transplant from many years before. The post-transplant medication he had been taking to weaken his immune system and keep it from attacking the donated kidney had also enabled a virus called Epstein-Barr (EBV) to run rampant and lead to lymphoma.

When Stewart came to Ohio State’s Comprehensive Cancer Center – James Cancer Hospital and Solove Research Institute (OSUCCC – James), he enrolled in an antiviral drug therapy clinical trial led by Michael Caligiuri, MD, whose laboratory, along with collaborators at OSU, had devised an animal model of human central nervous system (CNS) lymphoma.  Researchers hypothesized that novel drug therapies targeting EBV and lymphoma cells in the lab could be explored in humans with EBV and primary CNS lymphoma. 

“Dr. Caligiuri said I’d be the first patient with transplant-related primary CNS lymphoma to undergo this therapy,” Stewart says.  “I jumped at the chance.”  Less than a year later, the tumor was gone, and Stewart remains cancer-free – a prime example of a patient benefiting from innovative, science-based treatment. 


The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu