Publications

Rose KM, Stelter DA, and Jacob ST. (1981) Protein kinase activity of RNA polymerase I purified from rat hepatoma: Probable function of Mr 42,000 and 24,600 polypeptides. Proc. Natl. Acad. Sci. US 78:2833-37.

Rose KM, Bell L, and Jacob ST. (1977) Specific inhibition of chromatin-associated poly(A) synthesis in vitro by cordycepin 5’-triphosphate. Nature 267:178-80

Terns M, Jacob ST. (1989) Role of poly(A) polymerase in the cleavage and polyadenylation of mRNA precursor. Mol Cell Biol, 9:1435-1444

Zhang J, Jacob ST. (1990) Purification and characterization of a novel factor which stimulates rat ribosomal gene transcription in vitro by interacting with enhancer and core promoter elements. Mol Cell Biol, 10:5177-5186

Ghoshal K, Jacob ST. (1991) Ara-ATP impairs 3’-end processing of pre-mRNAs by inhibiting both cleavage and polyadenylation. Nucl Acids Res, 19(21): 5871-5875 PMID: 1719481

Hoff CM, Ghosh AK, Prabhakar BS, Jacob ST. (1994) Enhancer 1 binding factor, a Ku-related protein, is a positive regulator of RNA polymerase I transcription initiation Proc Natl Acad Sci USA. 91: 762-6 PMID: 8290597

Niu H, Jacob ST. (1994) E1BF, a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor. Association of a repressor activity with purified E1BF in serum deprived cells. Proc Natl Acad Sci USA, 91:9101-9105 PMID: 8090777

Liu Z, Jacob ST. (1994) Characterization of a protein that interacts with the rat ribosomal gene promoter and modulates RNA polymerase I transcription. J Biol Chem, 269:16618-16626 PMID: 8206980

Ghoshal, K. and Jacob, S.T. (1994) Specific inhibition of pre-rRNA processing in extracts from the lymphosarcoma cells treated 5-flurouracil. Cancer Research. 54:632-636 PMID: 8306322

Jacob ST. (1995) Regulation of ribosomal gene transcription Biochem J. 306:617-26 PMID: 7702552

Datta PK, Ghosh AK, Jacob ST. (1995) The RNA polymerase I promoter-activating factor CPBF is functionally and immunologically related to the basic helix-loop-helix-zipper DNA binding protein USF J Biol Chem, 270:8637 41 PMID: 7721765

Ghosh AK, Datta PK, Jacob ST. (1997) The dual role of Helix-Loop-Helix-Zipper protein USF in ribosomal RNA gene transcription in vivo. Oncogene, 14:589-594 PMID: 9053857

Datta PK, Budhiraja S, Reichel RR, Jacob ST. (1997) Regulation of ribosomal RNA gene transcription during retinoic acid-induced differentiation of mouse teratocarcinoma cells Exp cell Res. 231: 198-205 PMID 9056427

Ghoshal K, Jacob ST. (1997) An alternative molecular mechanism of action of 5-fluorouracil, a potent anticancer drug Biochem Pharmacol 53: 1569-75 PMID: 9264308

Ghoshal K, Wang Y, Sheridan J, Jacob ST. (1998) Transcriptional control of metallothionein induction in response to physical stress: transcription control, adaptation to stress and role of glucocorticoid. J Biol Chem, 273:2794 27910 PMID: 9774402

Jacob ST, Ghoshal K, Sheridan JF. (1999) Induction of metallothionein by stress and its molecular mechanisms Gene Expr. 7: 301-10 PMID: 10440231

Jacob ST, Ghosh AK. (1999) Control of RNA polymerase I-directed transcription: recent trends J Cell Biochem 33:41-50 PMID: 10629102

Majumder S, Ghoshal K, Li Z, Jacob ST. (1999) Hypermethylation of metallothionein-I promoter and suppression of its induction in cell lines overexpressing the large subunit of Ku protein. J Biol Chem, 274:28584-28589 PMID: 10497224

Ghoshal K, Majumder S, Li Z, Dong X, Jacob ST. (2000) Suppression of metallothionein gene expression in a rat hepatoma due to promoter-specific methylation. J Biol Chem, 275:539-547 PMID: 10617649

Ghoshal K, Jacob ST. (2001) Regulation of metallothionein gene expression Prog Nucleic Acid Res Mol Biol. 66:357-84 PMID: 11051769

Ghoshal K, Majumder S, Jacob ST. (2002) Analysis of promoter methylation and its role in silencing metallothionein-I gene in tumor cells: Methods in Enzymology 353:476-486 PMID: 12078520

Ghoshal K, Majumder S, Zhu Q, Hunzeker J, Datta J, Shah M, Sheridan JF, Jacob ST. (2002) Influenza virus infection induces metallothionein gene expression in the mouse liver and lung by overlapping but distinct molecular mechanisms. Mol Cell Biol, 24:8301-8317 PMID: 11713267

Majumder S, Ghoshal K, Datta J, Bai S, Dong X, Quan N, Plass C, Jacob ST. (2002) Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma. J Biol Chem, 277(18): 16048-16058 PMID: 11844796

Ghoshal K, Datta J, Majumder S, Dong X, Parthun M, Jacob ST. (2002) Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein-I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Mol Cell Biol, 22:8302-8319 PMID: 12417732

Dong X, Ghoshal K, Majumder S, Yadav SP, Jacob ST. (2002) Mitochondrial transcription factor A and its downstream targets are upregulated in a rat hepatoma. J Biol Chem, 277,43309-18 PMID: 12198131

Majumder, S., Ghoshal, K., Summers, D., Bai, S., Datta, J., and Jacob, S. T. (2003) Chromium (VI) downregulates heavy metal-induced metallothionein gene transcription by modifying transactivation potential of the key transcription factor MTF-1. J. Biol. Chem. 278, 2616-2626 PMID: 12716893

Motiwala, T., Ghoshal, K., Das, A., Majumder, S., Weichenhan, D., Wu, Y., Holman, K., James, S.J., Jacob, S.T.*, and Plass, C. (2003) Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene, 22:6319-6332 PMID: 14508512

Ghoshal, K., Majumder, S., Sharma, S., Datta, J., and Jacob, S.T. (2003) Role of human ribosomal RNA (rRNA) promoter methylation and of methyl CpG binding protein MBD2 in the suppression of rRNA gene expression. J. Biol. Chem. 279:6783-93 PMID: 14610093

Majumder, S., Varadharaj, S., Ghoshal, K., Monanai, U., Burghes, A.H.M., and Jacob, S.T. (2003) Identification of a novel cyclic AMP response element (CRE-II) and the role of CREB-1 in the cAMP-induced expression of the survival motor neuron (SMN) gene.  J. Biol Chem 279:14803-11 PMID: 14742439

Motiwala, T., Kutay, H., Ghoshal, K., Bai, S., Seimiya, H., Tsurua, T., Suster, S., Morrison, C., and Jacob, S.T. (2004). Receptor-type protein tyrosine phosphatase (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer  Proc.Natl.Acad.Sci.U.S., 101:13844-13849 PMID: 15356345

Bai, S, Ghoshal, K, Datta, J, Majumder, S, Yoon, S, and Jacob, S.T (2005), DNA methyltransferase 3b regulates NGF-mediated differentiation of PC12 cells by recruiting histone deacetylase 2 Mol.Cell.Biol. 25:751-766 PMID: 15632075

Ghoshal,K., Datta, J., Majumder, S., Bai, S., Kutay, H., Motiwala, and Jacob, S.T(2005) 5-Aza-Deoxycytidine induces selective degradation of DNA methyltransferase I by proteasomal pathway that requires the KEN box, Bromo-Adjacent Homology Domain, and Nuclear Localization Signal. Mol. Cell. Biol.25: 4727-4741(Ranked one of the top 10 papers by Faculty 1000) PMID: 15899874

Datta, J, Majumder, S, Bai, S, Ghoshal, K., Kutay H., Smith , D, Crabb J and Jacob, S T. (2005). Physical and functional interaction of Dnmt3a with Mbd3 and Brg1 in mouse lymphosarcoma cells.  Cancer Research. 65:10891-10900. PMID: 16322236

Jacob ST, Motiwala T.(2005) Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy. Cancer Gene Therapy, 12:665-672 PMID: 15803146

Bai S, Ghoshal K, Jacob ST. (2006) Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cells J Biol Chem. 281:13604-11 PMID: 16537533

Majumder,S, Ghoshal,K, Datta,J, Smith,D.S, Bai,S and Jacob,S.T (2006) Role of  DNA methyltransferases in regulation of human ribosomal RNA gene transcription J. Biol.Chem. 281: 22062-22072. PMID: 16735507

Kutay,H, Bai,S, Datta,J, Motiwala,T, Pogribny,I, Frankel,W, Jacob,S.T, and Ghoshal,K (2006) Downregulation of miR-122 in the rodent and human hepatocellular carcinomas J.Cell.Biochem. 99: 671-678 PMID: 16924677

Motiwala, T., and Jacob, S.T.(2006) Role  of protein tyrosine phosphatases in cancer. Prog. Nucleic Acid Research & Mol.Biol., 81:297-329 PMID: 16891175

Datta,J., Majumder,S., Kutay, H., Motiwala, T., Frankel, W., Costa, R., Cha, H.K., Macdougald, O.A., Jacob, S.T., and Ghoshal, K. (2007) Metallothionein expression is suppressed in primary human hepatocellular carcinomas and is mediated through inactivatin of C/EBPa by phosphatidyl inositol 3 kinase signaling cascade. Cancer Res., 67:2736-2746 PMID: 17363595

Motiwala, T., Majumder, Kutay, H., Smith, D. S., Neuberg, D. S., Lucas, D. M., Byrd, J. C., Grever, M., and Jacob, S. T. (2007) Methylation and silencing of protein tyrosine phosphatase receptor-type O in chronic lymphocytic leukemia. Clinical Cancer Res., 13:3174-3181. PMID: 17545520

Pal S, Baiocchi RA, Byrd JC, Grever MR, Jacob ST, Sif S. (2007) Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma. EMBO J. 26:3558-3569. PMID: 17627275

Bai S, Datta J, Jacob ST, Ghoshal K. (2007) Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain J Biol Chem. 282: 27171-80 PMID: 17631504

Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, Patel T. (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-58 PMID: 17681183

Datta,J, Ghoshal,K, Kutay,H, Nasser,M, Nuovo,G,Wang,B, Majumder,S, Lu,C, Volinia,S, Croce,C, Schmittgen,T and.Jacob,S.T (2008) Methylation Mediated Silencing of MicroRNA-1-1 gene in hepatocellular carcinoma: Role of miR-1 as negative regulator of tumor cell growth, Cancer Res 68: 5049–58. PMID: 18593903

Miller, T.E, Ghoshal,K, Ramaswamy,B, Roy,S, Datta,J, Shaprio,C.L, Jacob,S.T.  and  Majumder,S (2008) MicroRNA-221/222 confers tamoxifen  resistance in breast cancer by targeting p27(Kip1), J. Biol.Chem., 283: 29897-29903

Nasser,M.W, Datta,J, Nuovo,G, Kutay,H, Motiwala,T, Majumder,S, Wang,B, Suster,S, Jacob, S.T, and Ghoshal,K (2008) Downregulation of microRNA-1 (miR-1) in lung cancer: Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin induced apoptosis bymiR-1, J. Biol.Chem., 283: 33394-33405 PMID: 18818206

Motiwala,T, Majumder,S, Ghoshal,K, Kutay,H, Datta,J, Roy,S, Lucas,D.M, and Jacob, S.T (2009) PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells, J. Biol. Chem., 284: 455-464 PMID: 18997174

Datta, J, Ghoshal, K, Denny, W, Gamage, S.A, Brooke, D. G, Phiasivongsa, P, Redkar, S, Jacob, S.T (2009) A new class of quinoline-based hypomethylating agents reactivates tumor suppressor genes by inhibiting DNA methyltransferase 1 activity and inducing its degradation, Cancer Res., 69:4277-7285 PMID: 19417133

Ramaswamy, B, Majumder, S, Roy, S, Ghoshal, K, Kutay, H, Datta, J Younes, M, Shapiro, C.L, Motiwala, T, and Jacob, S.T. (2009) Estrogen Mediated Suppression Of The Gene Encoding Protein Tyrosine Phosphatase PTPRO In Human Breast Cancer: Mechanism And Role In Tamoxifen Sensitivity, Mol. Endo. 23:176-187 PMID: 19095770

Wang, B, Majumder, S, Nuovo, G, Kutay, H, Volinia, S, Patel, T, Schmittgen, T.D, Croce, C, Ghoshal, K, and Jacob, S.T (2009) Role of miR-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid defined diet in C57BL/6 mice, Hepatology., 50:1152-62 PMID: 19711427

Majumder S, Alinari L, Roy S, Miller T, Datta J, Sif S, Baiocchi R, Jacob ST. (2009) Methylation of histone H3 and H4 by PRMT5 regulates ribosomal RNA gene transcription, J Cell Biochem. 109:553-63 PMID: 19998411

Wang, B, Hsu, SH, Majumder, S, Kutay, H, Huang, W, Jacob, S.T, Ghoshal, K.(2009) TGFβ mediated upregulation of hepatic miR-181b promotes hepatocarcinogenesis by targeting TIMP3 , Oncogene. In Press. PMID: 20023698

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu