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Molecular Biology / Cancer Genetics Clinical Trials

Protocol No.PITitle
OSU-0107Doreen AgneseProspective Cohort Study of BRCA1 & BRCA2 Carriers
OSU-10129Dawn AllainThe Value of Genetic Counselors in Genetic Testing for Hereditary Breast-Ovarian Cancer
OSU-06016Sanford BarskyThe Bone marrow Stem Cell Origin of Solid Cancers in Humans and Transgenic Mice.
OSU-06017Sanford BarskyClues to the Stem Cell Origin of Human Cancers by Studying a Registry of Organ Transplant Recipients.
OSU-06056Sanford BarskyUse and Validation of Virtual Algorithms on TMA and Individual Microscope Slides to Detect Cancer Cells and Quantitate Immunocytochemical Staining for Select Nuclear, Cytoplasmic and Membrane Antigens.
CALGB-9760Clara BloomfieldMultidrug Resistance Studies in AML
CALGB-9862Clara BloomfieldMolecular Features of Acute Lymphoblastic Leukemia
CALGB-8461Clara BloomfieldCytogenetic Studies in Acute Leukemia [Dr. Clara Bloomfield, National Study Chair]
OSU-1997CO194Michael CaligiuriOSUCCC Leukemia Tissue Bank
OSU-07030William CarsonAnalysis of Micro-RNA Species in Melanoma.
OSU-13114William CarsonA Storage Facility for Tissues Obtained from Patients with Malignant Melanoma.
OSU-12140Arnab ChakravartiMolecular markers of prostate carcinoma
OSU-09024Beth ChristianA phase I/II study of veltuzumab (IMMU-106, hA20), a humanized anti-CD20 monoclonal antibody, combined with milatuzumab (IMMU-115, hLL1), a humanized anti-CD74 monoclonal antibody, in relapsed and refractory B-cell non-Hodgkin's lymphoma
OSU-06036Frederick DavidorfGenetics of Hereditary Uveal Melanoma.
OSU-0358Frederick DavidorfMolecular Genetic Profiling of Uveal Melanomas
OSU-05090Albert de la ChapelleStorage of Biological Material for the Discovery and Characterization of Genes Involved in Hereditary Disease Predisposition.
OSU-9812Albert de la ChapelleA Strategy to Search for Genes Predisposing to Papillary Carcinoma of the Thyroid When Mutated
OSU-9952Albert de la ChapelleStorage of DNA/RNA for the Discovery of Genes Involved in Cancer Predisposition - A Tissue Collection Study
OSU-06005Albert de la ChapelleCharacterization of Mutations in the PMS2 Gene in Samples from the Human Cancer genetics Sample Bank.
OSU-07013Albert de la ChapelleThe Identification of Predisposing Genes in Hyperplastic Polyposis (HPP)
OSU-09060Albert de la ChapelleEvaluation of In Vivo and In Vitro Pharmacology and Toxicology of Preventive Agents by Proteomics Using Human Mutant Cells from Dominantly Heritable Cancers: Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer (HNPCC)
OSU-07087Albert de la ChapelleCharacterization of Potential Susceptibility Genes in Chronic Lymphocytic Leukemia (CLL)
OSU-11002Yvonne EfeberaAssessment of MicroRNA Expression in Acute Graft-versus-Host Disease
OSU-10130James ElderNIH 1308: The Cancer Genome Atlas Patient Enrollment and Specimen Qualification Criteria Grade II-IV Gliomas
OSU-12194Michael GreverClinical Research in Hairy Cell Leukemia: Surveillance and Documentation of Clinical Outcomes in a Rare Form of Adult Leukemia
OSU-0449Denis GuttridgeAssessment of NFkB in Muscle Wasting Associated with Cancer-Induced Cachexia
OSU-05059Tsonwin HaiInvestigation of a Potential New Oncogene
OSU-10115Craig HofmeisterBuckeye Surveillance, Contact, and Research for Multiple Myeloma and Amyloidosis
OSU-06032Richard KloosThe Endocrine Neoplasia Repository (ENR).
OSU-11126Richard KloosSalivary gland damage and dysfunction in patients with differentiated thyroid cancer treated with radioactive iodine.
OSU-0456Jas LangTissue Procurement and Database for the Study of Molecular Events in Primary, Recurrent, and Metastatic Squamous Cell Carcinoma of the Head and Neck.
OSU-12042Greg LesinskiThe Effect of a Soy Bread Diet Intervention on Immune Function in Men with Prostate Cancer
OSU-05019Guido MarcucciAssessment of Aberrant Expression of Leukemic Markers in Normal CD34+ Hematopoietic Precursors.
OSU-05061Guido MarcucciMolecular Studies in Acute Myeloid Leukemia
CALGB-9665Guido MarcucciLeukemia Tissue Bank [Dr. Michael Caligiuri, National Study Chair]
OSU-07110Amir MortazaviOptimizing Human Urine Protein Extraction
OSU-12129Thomas OlenckiThe High-Dose Aldesleukin (IL-2) "Select" Trial: A PROSPECTIVE TISSUE COLLECTION PROTOCOL TO INVESTIGATE PREDICTIVE MODELS OF RESPONSE TO HIGH DOSE IL-2 TREATMENT IN PATIENTS WITH ADVANCED MELANOMA
OSU-12183Greg OttersonA Single-Arm Phase 2 Study of BMS-936558 in Subjects with Advanced or Metastatic Squamous Cell Non-Small Cell Lung Cancer Who Have Received At Least Two Prior Systemic Regimens
OSU-12184Greg OttersonLung Cancer Mutation Consortium Protocol
OSU-12053Greg OttersonA Randomized Phase II Trial of Erlotinib Alone or In Combination with Bevacizumab in Patients With Non-Small Cell Lung Cancer and Activating Epidermal Growth Factor Receptor Mutations
OSU-12068Greg OttersonLUX-Lung 8: A randomized, open-label Phase III trial of afatinib versus erlotinib in patients with advanced squamous cell carcinoma of the lung as second-line therapy following first-line platinum-based chemotherapy
OSU-11144Greg OttersonA RANDOMIZED, PHASE III, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING THE EFFICACY AND SAFETY OF MetMAb IN COMBINATION WITH TARCEVA (ERLOTINIB) IN PATIENTS WITH MET DIAGNOSTIC−POSITIVE NON−SMALL CELL LUNG CANCER (NSCLC) WHO HAVE RECEIVED STANDARD CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE
OSU-11192Greg OttersonRandomized Phase II Study of Single Agent OSI-906, an Oral, Small Molecule, Tyrosine Kinase Inhibitor (TKI) of the Insulin Growth Factor-1 Receptor (IGF-1R) Versus Topotecan for the Treatment of Patients with Relapsed Small Cell Lung Cancer (SCLC)
OSU-06083Christoph PlassThe Identification of Predisposing Genes in Chronic Lymphocytic Leukemia (CLL).
OSU-11127Leigha Senter-JamiesonThe impact of pregnancy during and after breast cancer on survival in carriers of BRCA1 and BRCA2 mutations
OSU-07088Charles ShapiroThe Columbus Breast Cancer Tissue Bank
OSU-06070Stephan TannerGenetic Classification of Juvenile Cobalamin Deficiency.
OSU-07014Amanda TolandGenetic Modifiers of Breast and Ovarian Cancer Risk
OSU-05078Amanda TolandGenomic Analysis of Squamous Cell Carcinoma
OSU-05082Amanda TolandVariants in High Risk Breast Cancer Genes and Contribution to Cancer Risk.
OSU-05102Amanda TolandIdentification of Human Cancer Susceptibility & Resistance Genes.
OSU-05092James Van BrocklynThe Role Shingosine Kinase in Astrocytic Gliomas.
OSU-12020Robert WesolowskiMINT I Multi-Institutional Neo-adjuvant Therapy MammaPrint project I
CALGB-40903Lisa YeePHASE II STUDY OF NEOADJUVANT LETROZOLE FOR POSTMENOPAUSAL WOMEN WITH ESTROGEN RECEPTOR POSITIVE DUCTAL CARCINOMA IN SITU [DCIS)