Jeffrey Parvin MD, PhD
Jeffrey Parvin MD, PhD
904 BRT 460 West 12th Avenue Columbus OH 43210
- Molecular Biology and Cancer Genetics
General Research Interestbreast cancer, systems biology, molecular biology
Research DescriptionResearch in the Parvin lab focuses on the biological processes involved in breast cancer. We focus on pathways regulated by the BRCA1 and BRCA2 tumor suppressor proteins, and these include the repair of DNA damage, control of transcription, control of cell cycle progression, and centrosome control. We use a variety of methods that include the use of informatics to generate hypotheses and biochemical and molecular biology experiments using tissue culture models.
Transinstitutional WorkAs Director of the Biomedical Shared Resource, Dr. Parvin collaborates with a number of OSU labs in the analysis of data-intensive experiments, such as gene expression analysis and next-generation sequence analysis. The Parvin laboratory collaborates with the Huang and Catalyurek groups to develop new informatics methods for deriving biologically useful hypotheses that can be tested in the laboratory. The laboratory collaborates with breast cancer physicians in order to develop new antibody-based biomarker methods for the evaluation of breast cancer cases. The Parvin laboratory is also in the Tumor Microenvironment program.
Wang J, Lan X, Hsu PY, Hsu HK, Huang K, Parvin J, Huang TH, Jin VXGenome-wide analysis uncovers high frequency, strong differential chromosomal interactions and their associated epigenetic patterns in E2-mediated gene regulation.BMC Genomics 14 70 1/31/2013
Arora M, Zhang J, Heine GF, Ozer G, Liu HW, Huang K, Parvin JPromoters active in interphase are bookmarked during mitosis by ubiquitination.Nucleic Acids Res 40(20) 10187-202 11/1/2012
Liu HW, Zhang J, Heine GF, Arora M, Gulcin Ozer H, Onti-Srinivasan R, Huang K, Parvin JChromatin modification by SUMO-1 stimulates the promoters of translation machinery genes.Nucleic Acids Res 40(20) 10172-86 11/1/2012
Zhang J, Lu K, Xiang Y, Islam M, Kotian S, Kais Z, Lee C, Arora M, Liu HW, Parvin J, Huang KWeighted frequent gene co-expression network mining to identify genes involved in genome stability.PLoS Comput Biol 8(8) e1002656 1/1/2012
Kais Z, Barsky SH, Mathsyaraja H, Zha A, Ransburgh DJ, He G, Pilarski R, Shapiro CL, Huang K, Parvin JDKIAA0101 interacts with BRCA1 and regulates centrosome number.Mol Cancer Res 9(8) 1091-9 8/1/2011
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