John Phay MD


John Phay MD
Assoc Professor - ClinicalCollege of Medicinephay.1@osu.edu
N924 Doan Hall 410 W 10th Avenue Columbus Ohio 43210
Phone:614-293-8550Fax: (614) 293-3465
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Phay has two main research projects. The first is examining a novel AMPK activator for the treatment of thyroid cancer. Dr. Phay's research has shown in multiple human thyroid cancer cell lines that OSU-53 has inhibited growth at concentrations equal or lower than in breast cancer cells, and a dose and time-dependent activation of AMPK. He is currently studying the mechanism of action to potentially use synergistically with known BRAF inhibitors. The second research project is creating a molecular imaging agent for medullary thyroid cancer (MTC) and parathyroid tumors. The calcium sensing-receptor (CaSR) is expressed primarily on parathyroids, thyroid C-cells, and the kidney, as well as in MTC. Further development may allow pre-operative and intra-operative detection to improve surgical outcomes.

Current Publications

  • McWade MA, Paras C, White LM, Phay JE, Solórzano CC, Broome JT, Mahadevan-Jansen ALabel-free Intraoperative Parathyroid Localization with Near-Infrared Autofluorescence Imaging.J Clin Endocrinol Metab in press jc20142503 8/22/2014
  • Shulman LN, Smerage JB, Stevenson MM, Varadhachary GR, Zager JS, Zhen WK, Bergman MA, Freedman-Cass DA, Gilcrease GW, Godby K, Iyer R, Lenzi R, Phay J, Rashid A, Saltz L, Schwab RB, Ettinger DS, Handorf CR, Agulnik M, Bowles DW, Cates JM, Cristea M, Dotan E, Eaton KD, Fidias PM, Gierada DOccult primary, version 3.2014.J Natl Compr Canc Netw 12 969-74 7/1/2014
  • Phay JE, Ringel MDMetastatic mechanisms in follicular cell-derived thyroid cancer.Endocr Relat Cancer 20 R307-19 12/1/2013
  • McWade MA, Paras C, White LM, Phay JE, Mahadevan-Jansen A, Broome JTA novel optical approach to intraoperative detection of parathyroid glands.Surgery 154 1371-7; discussion 1377 12/1/2013
  • Yusof AM, Kothandaraman S, Zhang X, Saji M, Ringel MD, Tweedle MF, Phay JEDevelopment of a calcium-sensing receptor molecular imaging agent.Surgery 154 1378-84; discussion 1384 12/1/2013
  • Ding H, Yusof AM, Kothandaraman S, Saji M, Wang C, Kumar K, Milum K, Carleton M, Pan X, Ringel MD, Tweedle MF, Phay JELocalization of CaSR antagonists in CaSR-expressing medullary thyroid cancer.J Clin Endocrinol Metab 98 E1722-9 11/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu