Nam Yong Lee PhD


Nam Yong Lee PhD
Asst ProfessorCollege of Pharmacylee.5064@osu.edu
536 Parks Hall 500 W 12th Avenue Columbus OH 43210
Phone:614-292-3546Fax:
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Lee's research focuses on how transforming growth factor beta (TGF beta) signaling regulates vascular functions during tumor development and metastasis. Dr. Lee's lab is particularly interested in understanding the role of two endothelial-specific TGF beta receptors, endoglin and ALK1, which are essential regulators of angiogenesis and tumor vascularization. As both endoglin and ALK1 are emerging as promising vascular targets in clinical trials, defining their signaling and cellular functions will be critical to predict potential mechanisms of resistance and identify patients who will most likely benefit from endoglin and ALK1-targeted therapies or combination therapies.

Current Publications

  • Kumar S, Shah N, Hoyt DG, Hawinkels LJ, Mythreye K, Lee NY, Pan CCSrc-mediated Post-translational Regulation of Endoglin Stability and Function Is Critical for Angiogenesis.J Biol Chem 289 25486-96 9/12/2014
  • Kumar S, Pan CC, Bloodworth JC, Nixon AB, Theuer C, Hoyt DG, Lee NYAntibody-directed coupling of endoglin and MMP-14 is a key mechanism for endoglin shedding and deregulation of TGF-β signaling.Oncogene 33 3970-9 7/24/2014

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu