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Fen Xia MD, PhD


Fen Xia MD, PhD
Assoc ProfessorCollege of Medicinefen.xia@osumc.edu
Starling Loving 300 W 10th Avenue Columbus OH 43210
Phone:614-366-5091Fax:
  • Molecular Biology and Cancer Genetics

General Research Interest

Breast and pancreatic cancer, malignant Brain tumor, molecular and cellular biology

Research Description

Research in the Xia laboratory focuses on elucidating the mechanisms that regulate the repair of chromosomal double-strand breaks (DSB) that arise during physiological DNA metabolism and after radiation therapy or chemotherapy. We aim to understand 1) the impact of deregulated DSB repair on carcinogenesis and the development of tumor resistance to therapy and 2) to explore novel avenues of cancer treatment targeting the DSB repair pathways. We have developed an array of intrachromosomal and extrachromosomal repair substrates that allow analysis of the quantity and quality of DSB repair by different mechanisms in mammalian cells. An understanding of the defects of DNA repair and its interplay with cell death within tumors; as well as the crosstalk between tumor cell DNA replication/repair process with its microenvironment may offer novel avenues for both cancer prevention and tailored therapy.

Current Publications

  • Jiang G, Plo I, Wang T, Rahman M, Cho JH, Yang E, Lopez BS, Xia FBRCA1-Ku80 protein interaction enhances end-joining fidelity of chromosomal double-strand breaks in the G1 phase of the cell cycle.J Biol Chem 288(13) 8966-76 3/29/2013
  • Yang ES, Nowsheen S, Rahman MA, Cook RS, Xia FTargeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition.Cancer Res 72(21) 5547-55 11/1/2012
  • Wentz SC, Zhao ZG, Shyr Y, Shi CJ, Merchant NB, Washington K, Xia F, Chakravarthy ABLymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma.World J Gastrointest Oncol 4(10) 207-15 10/15/2012