Christin Burd E PhD


Christin Burd E PhD
Asst ProfessorCollege of Arts and Sciencesburd.25@osu.edu
Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-7569Fax: (614) 688-4245
  • Molecular Biology and Cancer Genetics

General Research Interest

The Role of the INK4/ARF locus in cancer and aging

Research Description

The INK4/ARF locus encodes three tumor suppressor genes frequently lost or silenced in human cancers (p15INK4b, p16INK4a, and p14ARF). Dr. Burd's lab aims to faithfully recapitulate the genetics of these tumors through the development of genetically engineered mouse models. In addition, they have pioneered in vivo imaging techniques that allow us to track the formation and progression of spontaneous cancers. Use of these technologies will provide mechanistic insight into the molecular processes governing tumor initiation, progression and therapeutic resistance. It is the goal to bridge the gap between bench science and clinical trials, generating faithful models for drug discovery and efficacy studies.

Current Publications

  • Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NEMutation-Specific RAS Oncogenicity Explains N-RAS Codon 61 Selection in Melanoma.Cancer Discov in press 9/24/2014
  • Jeck WR, Parker J, Carson CC, Shields JM, Sambade MJ, Peters EC, Burd CE, Thomas NE, Chiang DY, Liu W, Eberhard DA, Ollila D, Grilley-Olson J, Moschos S, Neil Hayes D, Sharpless NETargeted next generation sequencing identifies clinically actionable mutations in patients with melanoma.Pigment Cell Melanoma Res 27 653-63 7/1/2014
  • LaPak KM, Burd CEThe molecular balancing act of p16(INK4a) in cancer and aging.Mol Cancer Res 12 167-83 2/1/2014
  • Sorrentino JA, Krishnamurthy J, Tilley S, Alb JG Jr, Burd CE, Sharpless NEp16INK4a reporter mice reveal age-promoting effects of environmental toxicants.J Clin Invest 124 169-73 1/2/2014
  • Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NEMonitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.Cell 152 340-51 1/17/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu