Zucai Suo PhD


Zucai Suo PhD
ProfessorArts and Sciencessuo.3@osu.edu
880 Bioscience Building 484 W 12th Avenue Columbus Ohio 43210
Phone:614-688-3706Fax: (614) 292-6773
  • Molecular Biology and Cancer Genetics

General Research Interest

Employing advanced enzymology to investigate DNA polymerases, kinases, and proteases.

Research Description

The three major research projects in the Suo laboratory are: 1) using pre-steady state kinetic techniques (rapid chemical quench flow and stopped flow) and single molecule methods to elucidate kinetic mechanisms for DNA polymerases, kinases, and proteases; 2) develop small molecules to inhibit hepatitis C infections; and 3) investigate the efficacy and toxicity of antiviral and anticancer nucleoside analogs.

Transinstitutional Work

We have collaborated with the following groups in the past several years: Dr. Hong Ling, an X-ray Crystallographer at University of Western Ontario, Canada; Dr. John-Stephen Taylor, a chemist at Washington University at St. Louis; and Dr. Ashis Basu, a chemist at University of Connecticut.  

Current Publications

  • Xu C, Maxwell BA, Suo ZConformational Dynamics of Thermus aquaticus DNA Polymerase I during Catalysis.J Mol Biol 426 2901-17 8/12/2014
  • Vyas R, Zahurancik WJ, Suo ZStructural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase λProc Natl Acad Sci U S A in press 7/11/2014
  • Taggart DJ, Fredrickson SW, Gadkari VV, Suo ZMutagenic potential of 8-oxo-7,8-dihydro-2'-deoxyguanosine bypass catalyzed by human Y-family DNA polymerases.Chem Res Toxicol 27 931-40 5/19/2014
  • Maxwell BA, Suo ZRecent insight into the kinetic mechanisms and conformational dynamics of Y-Family DNA polymerases.Biochemistry 53 2804-14 5/6/2014
  • Maxwell BA, Xu C, Suo ZConformational dynamics of a Y-family DNA polymerase during substrate binding and catalysis as revealed by interdomain Förster resonance energy transfer.Biochemistry 53 1768-78 3/25/2014
  • Qin Y, Yang Y, Zhang L, Fowler JD, Qiu W, Wang L, Suo Z, Zhong DDirect probing of solvent accessibility and mobility at the binding interface of polymerase (Dpo4)-DNA complex.J Phys Chem A 117 13926-34 12/19/2013
  • Zahurancik WJ, Klein SJ, Suo ZKinetic mechanism of DNA polymerization catalyzed by human DNA polymerase ε.Biochemistry 52 7041-9 10/8/2013
  • Espinoza-Herrera SJ, Gaur V, Suo Z, Carey PRFollowing DNA chain extension and protein conformational changes in crystals of a Y-family DNA polymerase via Raman crystallography.Biochemistry 52 4881-90 7/23/2013
  • Maxwell BA, Suo ZSingle-molecule investigation of substrate binding kinetics and protein conformational dynamics of a B-family replicative DNA polymerase.J Biol Chem 288 11590-600 4/19/2013
  • Taggart DJ, Camerlengo TL, Harrison JK, Sherrer SM, Kshetry AK, Taylor JS, Huang K, Suo ZA high-throughput and quantitative method to assess the mutagenic potential of translesion DNA synthesis.Nucleic Acids Res 41 e96 4/1/2013
  • Göksenin AY, Zahurancik W, LeCompte KG, Taggart DJ, Suo Z, Pursell ZFHuman DNA polymerase ε is able to efficiently extend from multiple consecutive ribonucleotides.J Biol Chem 287 42675-84 12/14/2012
  • Sherrer SM, Taggart DJ, Pack LR, Malik CK, Basu AK, Suo ZQuantitative analysis of the mutagenic potential of 1-aminopyrene-DNA adduct bypass catalyzed by Y-family DNA polymerases.Mutat Res 737 25-33 9/1/2012
  • Wang Y, Chu X, Suo Z, Wang E, Wang JMultidomain protein solves the folding problem by multifunnel combined landscape: theoretical investigation of a Y-family DNA polymerase.J Am Chem Soc 134 13755-64 8/22/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu