Lawrence Kirschner S MD, PhD

Lawrence Kirschner S MD, PhD
ProfessorCollege of
579 McCampbell Hall 1581 Dodd Drive Columbus Ohio 43210
Phone:614-292-1190Fax: (614) 247-1622
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Kirschner's research is focused on endocrine tumor genetics, with specific interest in understanding how dysregulation of PKA contributes to tumorigenesis in cAMP-responsive tissues. Using a combination of in vivo mouse models and in vitro tissue culture work, his lab aims to understand how activated PKA cross-talks with a variety of other signaling pathways to produce tumors. As part of OSU’s thyroid cancer group, they have developed mouse models of benign and malignant follicular thyroid tumors which behave similarly to the human disease.

Current Publications

  • McCarty SK, Saji M, Zhang X, Knippler CM, Kirschner L, Fernandez S, Ringel MDBRAF activates and physically interacts with PAK to regulate cell motility.Endocr Relat Cancer in press 9/16/2014
  • Kirschner LSMedicine. A unified cause for adrenal Cushing's syndrome.Science 344 804-5 5/23/2014
  • Lee AA, Zhang X, Kirschner JM, Parlow AF, Saji M, Jarjoura D, Ringel MD, La Perle KM, Kirschner LS, Pringle DR, Vasko VV, Yu L, Manchanda PKFollicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.J Clin Endocrinol Metab 99 E804-12 5/1/2014
  • Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha RPKA signaling drives mammary tumorigenesis through Src.Oncogene in press 3/24/2014
  • Zhang M, Manchanda PK, Wu D, Wang Q, Kirschner LSKnockdown of PRKAR1A, the gene responsible for Carney complex, interferes with differentiation in osteoblastic cells.Mol Endocrinol 28 295-307 3/1/2014
  • Zhang M, Mahoney E, Zuo T, Manchanda PK, Davuluri RV, Kirschner LSProtein Kinase A Activation Enhances β-Catenin Transcriptional Activity through Nuclear Localization to PML Bodies.PLoS One 9 e109523 1/1/2014
  • Guo L, Lee AA, Rizvi TA, Ratner N, Kirschner LSThe protein kinase A regulatory subunit R1A (Prkar1a) plays critical roles in peripheral nerve development.J Neurosci 33 17967-75 11/13/2013
  • Manchanda PK, Jones GN, Lee AA, Pringle DR, Zhang M, Yu L, La Perle KM, Kirschner LSRac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors.Oncogene 32 3491-9 7/25/2013
  • Kirschner LSGaining traction in the treatment of adrenocortical carcinoma.J Clin Endocrinol Metab 98 45-7 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: