Research DescriptionDr. Huang, professor of human cancer genetics, is an established investigator in the field of cancer epigenomics. He has pioneered the development of high-throughput microarray technologies for deciphering complex interactions between DNA methylation and histone modifications in breast and ovarian cancers. These techniques, as well as massively parallel sequencing approaches, are being used in combination with statistical tools to develop models for heritable silencing of genes during tumor development. The identified epigenetic biomarkers are being used for early cancer detection. Four main projects are 1) develop epigenomic maps of estrogen-regulated genes in breast cancer; 2) identify xenoestrogen-induced methylation markers in breast stem/progenitor cells; 3) define microenvironmental factors that initiate epigenetic silencing in epithelial cells; 4) characterize TGF- target genes in ovarian cancer stem/initiating cells.
Dr. Huang is the Principal Investigator of three NIH grants and Co-Investigator of 3-4 federally funded projects and has published more than 145 peer-reviewed papers and book chapters.