Michael Freitas A PhD

Michael Freitas A PhD
Assoc ProfessorCollege of Medicinefreitas.5@osu.edu
906 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-8432Fax: (614) 292-0559
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Freitas' lab has developed extensive expertise in the field of clinical/translational proteomics, biomarker discovery/validation and bioinformatics for mass spectrometry based proteomics. Their work focuses on the determination of side chain modifications of proteins important in Chromatin Remodeling and relating these modifications to aberrant cellular function in cancer.

Current Publications

  • Harshman SW, Hoover ME, Huang C, Branson OE, Chaney SB, Cheney CM, Rosol TJ, Shapiro CL, Wysocki VH, Huebner K, Freitas MAHistone h1 phosphorylation in breast cancer.J Proteome Res 13 2453-67 5/2/2014
  • Guan X, Rastogi N, Parthun MR, Freitas MASILAC peptide ratio calculator: a tool for SILAC quantitation of peptides and post-translational modifications.J Proteome Res 13 506-16 2/7/2014
  • Freitas MA, Harshman SW, Young NL, Parthun MRH1 histones: current perspectives and challenges.Nucleic Acids Res 41 9593-609 11/1/2013
  • Singh R, Mortazavi A, Telu KH, Nagarajan P, Lucas DM, Thomas-Ahner JM, Clinton SK, Byrd JC, Freitas MA, Parthun MRIncreasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis.Nucleic Acids Res 41 9284-95 11/1/2013
  • Harshman SW, Chen MM, Branson OE, Jacob NK, Johnson AJ, Byrd JC, Freitas MAIsolation and analysis of linker histones across cellular compartments.J Proteomics 91 595-604 10/8/2013
  • Harshman SW, Canella A, Ciarlariello PD, Rocci A, Agarwal K, Smith EM, Talabere T, Efebera YA, Hofmeister CC, Benson DM Jr, Paulaitis ME, Freitas MA, Pichiorri FCharacterization of multiple myeloma vesicles by label-free relative quantitation.Proteomics 13 3013-29 10/1/2013
  • Guan X, Rastogi N, Parthun MR, Freitas MADiscovery of histone modification crosstalk networks by stable isotope labeling of amino acids in cell culture mass spectrometry (SILAC MS).Mol Cell Proteomics 12 2048-59 8/1/2013
  • Ge Z, Nair D, Guan X, Rastogi N, Freitas MA, Parthun MRSites of acetylation on newly synthesized histone H4 are required for chromatin assembly and DNA damage response signaling.Mol Cell Biol 33 3286-98 8/1/2013
  • Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob ST, Hsu SH, Motiwala TMethylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.J Cell Biochem 114 1810-8 8/1/2013
  • Telu KH, Abbaoui B, Thomas-Ahner JM, Zynger DL, Clinton SK, Freitas MA, Mortazavi AAlterations of histone H1 phosphorylation during bladder carcinogenesis.J Proteome Res 12 3317-26 7/5/2013
  • Kheterpal I, Newman S, Leonardi C, Freitas MA, Bunnell BA, Gimble JM, Sutton GM, Ptitsyn AA, Floyd ZE, Yu G, Wu X, Hamel K, Shah FS, Centanni A, Eilertsen KBiological aging alters circadian mechanisms in murine adipose tissue depots.Age (Dordr) 35 533-47 6/1/2013
  • Byrd JC, Volinia S, Shapiro CL, Freitas MA, Croce CM, Pichiorri F, Palmieri D, De Luca L, Consiglio J, You J, Rocci A, Talabere T, Piovan C, Lagana A, Cascione L, Guan J, Gasparini P, Balatti V, Nuovo G, Coppola V, Hofmeister CC, Marcucci GIn vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.J Exp Med 210 951-68 5/6/2013
  • Luechapanichkul R, Chen X, Taha HA, Vyas S, Guan X, Freitas MA, Hadad CM, Pei DSpecificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes.J Biol Chem 288 6498-510 3/1/2013
  • Rovin BH, Sen CK, Roy S, Freitas MA, Shapiro JP, Biswas S, Merchant AS, Satoskar A, Taslim C, Lin SA quantitative proteomic workflow for characterization of frozen clinical biopsies: laser capture microdissection coupled with label-free mass spectrometry.J Proteomics 77 433-40 12/21/2012
  • Arango D, Parihar A, Villamena FA, Wang L, Freitas MA, Grotewold E, Doseff AIApigenin induces DNA damage through the PKCδ-dependent activation of ATM and H2AX causing down-regulation of genes involved in cell cycle control and DNA repair.Biochem Pharmacol 84 1571-80 12/15/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu