Gustavo W Leone PhD


Gustavo W Leone PhD
ProfessorCollege of Medicineleone.24@osu.edu
592 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-4567Fax: 614-688-4245
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Leone’s laboratory studies the role of the Ras pathway in coordinating cell growth and cell death signals elicited by the E2F and Myc transcription programs.

Current Publications

  • Moreau JL, Artap ST, Shi H, Chapman G, Leone G, Sparrow DB, Dunwoodie SLCited2 is required in trophoblasts for correct placental capillary patterning.Dev Biol 392 62-79 8/1/2014
  • Saenz Robles MT, Chong JL, Koivisto C, Trimboli A, Liu H, Leone G, Pipas JMViral Oncogene Expression in the Stem/Progenitor Cell Compartment of the Mouse Intestine Induces Adenomatous Polyps.Mol Cancer Res in press 7/3/2014
  • Cecchini MJ, Thwaites MJ, Talluri S, MacDonald JI, Passos DT, Chong JL, Cantalupo P, Stafford PM, Sáenz-Robles MT, Francis SM, Pipas JM, Leone G, Welch I, Dick FAA retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.Mol Cell Biol 34 2029-45 6/1/2014
  • Rath KS, Naidu SK, Lata P, Bid HK, Rivera BK, McCann GA, Tierney BJ, Elnaggar AC, Bravo V, Leone G, Houghton P, Hideg K, Kuppusamy P, Cohn DE, Selvendiran KHO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer.Cancer Res 74 2316-27 4/15/2014
  • Veronese A, Pepe F, Chiacchia J, Pagotto S, Lanuti P, Veschi S, Di Marco M, D'Argenio A, Innocenti I, Vannata B, Autore F, Marchisio M, Wernicke D, Verginelli F, Leone G, Rassenti LZ, Kipps TJ, Mariani-Costantini R, Laurenti L, Croce CM, Visone RAllele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia.Leukemia in press 4/15/2014
  • Pelosi G, Haspinger ER, Bimbatti M, Leone G, Paolini B, Fabbri A, Tamborini E, Perrone F, Testi A, Garassino M, Maisonneuve P, de Braud F, Pilotti S, Pastorino UDoes immunohistochemistry affect response to therapy and survival of inoperable non-small cell lung carcinoma patients? A survey of 145 stage III-IV consecutive cases.Int J Surg Pathol 22 136-48 4/1/2014
  • Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner KUStat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.Mol Cell Biol 34 1363-77 4/1/2014
  • Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg LE, Sites E, Sandy A, Trimboli A, Fernandez SA, Eng C, Shapiro C, Leone GSelective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis.Oncogene in press 11/25/2013
  • Julian LM, Vandenbosch R, Pakenham CA, Andrusiak MG, Nguyen AP, McClellan KA, Svoboda DS, Lagace DC, Park DS, Leone G, Blais A, Slack RSOpposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells.Cell Stem Cell 12 440-52 4/4/2013
  • Liu B, Yi J, Sv A, Lan X, Ma Y, Huang TH, Leone G, Jin VXQChIPat: a quantitative method to identify distinct binding patterns for two biological ChIP-seq samples in different experimental conditions.BMC Genomics 14 Suppl 8 S3 1/1/2013
  • Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, Leone G, Cross JC, Wang HA positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.PLoS Biol 11 e1001536 1/1/2013
  • Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MCEts2 in tumor fibroblasts promotes angiogenesis in breast cancer.PLoS One 8 e71533 1/1/2013
  • Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone GCanonical and atypical E2Fs regulate the mammalian endocycle.Nat Cell Biol 14 1192-202 11/1/2012
  • Weijts BG, Bakker WJ, Cornelissen PW, Liang KH, Schaftenaar FH, Westendorp B, de Wolf CA, Paciejewska M, Scheele CL, Kent L, Leone G, Schulte-Merker S, de Bruin AE2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.EMBO J 31 3871-84 10/3/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu