Gustavo W Leone PhD


Gustavo W Leone PhD
ProfessorCollege of Medicineleone.24@osu.edu
592 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-4567Fax: 614-688-4245
  • Molecular Biology and Cancer Genetics

Current Publications

  • Selvendiran KHO-3867, a Safe STAT3 Inhibitor, Is Selectively Cytotoxic to Ovarian Cancer.Cancer Res 74 2316-27 4/15/2014
  • Visone RAllele-specific loss and transcription of the miR-15a/16-1 cluster in chronic lymphocytic leukemia.Leukemia 4/15/2014
  • Pastorino UDoes Immunohistochemistry Affect Response to Therapy and Survival of Inoperable Non-Small Cell Lung Carcinoma Patients? A Survey of 145 Stage III-IV Consecutive Cases.Int J Surg Pathol 22 136-48 4/1/2014
  • Wagner KUStat5 Regulates the Phosphatidylinositol 3-Kinase/Akt1 Pathway during Mammary Gland Development and Tumorigenesis.Mol Cell Biol 34 1363-77 4/1/2014
  • Dick FAA retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene targeted mice.Mol Cell Biol 3/24/2014
  • Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MCEts2 in tumor fibroblasts promotes angiogenesis in breast cancer.PLoS One 8(8) e71533 8/16/2013
  • Julian LM, Vandenbosch R, Pakenham CA, Andrusiak MG, Nguyen AP, McClellan KA, Svoboda DS, Lagace DC, Park DS, Leone GW, Blais A, Slack RSOpposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells.Cell Stem Cell 12(4) 440-52 4/4/2013
  • Lu J, Zhang S, Nakano H, Simmons DG, Wang S, Kong S, Wang Q, Shen L, Tu Z, Wang W, Wang B, Wang H, Wang Y, van Es JH, Clevers H, Leone GW, Cross JC, Wang HA positive feedback loop involving Gcm1 and Fzd5 directs chorionic branching morphogenesis in the placenta.PLoS Biol 11(4) e1001536 1/1/2013
  • Chen HZ, Ouseph MM, Li J, Pécot T, Chokshi V, Kent L, Bae S, Byrne M, Duran C, Comstock G, Trikha P, Mair M, Senapati S, Martin CK, Gandhi S, Wilson N, Liu B, Huang YW, Thompson JC, Raman S, Singh S, Leone M, Machiraju R, Huang K, Mo X, Fernandez S, Kalaszczynska I, Wolgemuth DJ, Sicinski P, Huang T, Jin V, Leone GWCanonical and atypical E2Fs regulate the mammalian endocycle.Nat Cell Biol 14(11) 1192-202 11/1/2012
  • Weijts BG, Bakker WJ, Cornelissen PW, Liang KH, Schaftenaar FH, Westendorp B, de Wolf CA, Paciejewska M, Scheele CL, Kent L, Leone GW, Schulte-Merker S, de Bruin AE2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.EMBO J 31(19) 3871-84 10/3/2012
  • Kim JW, Evans C, Weidemann A, Takeda N, Lee YS, Stockmann C, Branco-Price C, Brandberg F, Leone G, Ostrowski MC, Johnson RSLoss of fibroblast HIF-1α accelerates tumorigenesis.Cancer Res 72(13) 3187-95 7/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu