John Gunn S PhD


John Gunn S PhD
ProfessorCollege of Medicinegunn.43@osu.eduwebsite
1006 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-292-6036Fax: (614) 292-5495
  • Molecular Biology and Cancer Genetics

General Research Interest

Host-pathogen interactions, role of chronic infections in the development of cancer

Research Description

My laboratory performs research pertaining to microbial resistance to innate Immunity. Much of our research is focused on the macrophage, as well as the mucosal surface. We are interested in microbial (Salmonella/Francisella) mechanisms of resistance to innate immune components (i.e. antimicrobial peptides) and to killing by host phagocytes. In addition, we study Salmonella chronic carriage, which occurs in the human gallbladder and is associated with the presence of gallstones. Chronic carriage is linked to an increased risk of gallbladder/ hepatobiliary carcinoma. We are examining this in a mouse model. Discerning whether S. Typhi gallbladder carriage leads to cancer could significantly contribute to the early detection and/or prevention of gallbladder cancer. Further, this study will provide scientific evidence for the broader relationship between chronic infections and cancer.

Transinstitutional Work

Dr. Gunn's laboratory collaborates effectively with CCC faculty in the Davis Heart Lung Research Institute and Division of Infectious Diseases on a Francisella program project. He is also a part of a larger initiative to develop research collaborations between those interested in infectious diseases and those with expertise in experimental therapeutics. Additionally, Dr. Gunn is part of developing interest groups focused on antimicrobials, lipids, and on the study of biofilms in infectious diseases. Finally, Dr. Gunn has international human subjects collaborations that examine gallstones and the development and maintenance of the Salmonella carrier state.

Current Publications

  • Koopman JA, Marshall JM, Bhatiya A, Eguale T, Kwiek JJ, Gunn JSInhibition of Salmonella enterica biofilm formation using small-molecule adenosine mimetics.Antimicrob Agents Chemother in press 10/13/2014
  • Collier MA, Gallovic MD, Peine KJ, Duong AD, Bachelder EM, Gunn JS, Schlesinger LS, Ainslie KMDelivery of host cell-directed therapeutics for intracellular pathogen clearance.Expert Rev Anti Infect Ther 11 1225-35 11/1/2013
  • Gonzalez-Escobedo G, Gunn JSIdentification of Salmonella enterica serovar Typhimurium genes regulated during biofilm formation on cholesterol gallstone surfaces.Infect Immun 81 3770-80 10/1/2013
  • Gonzalez-Escobedo G, Gunn JSGallbladder epithelium as a niche for chronic Salmonella carriage.Infect Immun 81 2920-30 8/1/2013
  • Gonzalez-Escobedo G, La Perle KM, Gunn JSHistopathological analysis of Salmonella chronic carriage in the mouse hepatopancreatobiliary system.PLoS One 8 e84058 1/1/2013
  • Mohapatra NP, Soni S, Rajaram MV, Strandberg KL, Gunn JSType A Francisella tularensis acid phosphatases contribute to pathogenesis.PLoS One 8 e56834 1/1/2013
  • Charles RC, Sultana T, Alam MM, Yu Y, Wu-Freeman Y, Bufano MK, Rollins SM, Tsai L, Harris JB, LaRocque RC, Leung DT, Brooks WA, Nga TV, Dongol S, Basnyat B, Calderwood SB, Farrar J, Khanam F, Gunn JS, Qadri F, Baker S, Ryan ETIdentification of immunogenic Salmonella enterica serotype Typhi antigens expressed in chronic biliary carriers of S. Typhi in Kathmandu, Nepal.PLoS Negl Trop Dis 7 e2335 1/1/2013
  • Strandberg KL, Richards SM, Gunn JSCathelicidin antimicrobial peptide expression is not induced or required for bacterial clearance during salmonella enterica infection of human monocyte-derived macrophages.Infect Immun 80 3930-8 11/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu